Ignite Creation Date:
2024-05-06 @ 12:12 PM
Last Modification Date:
2024-10-26 @ 12:55 PM
Study NCT ID:
NCT03703947
Status:
RECRUITING
Last Update Posted:
2022-03-25
First Post:
2018-10-08
Brief Title:
Biomarker Profiling in Abdominal Aortic Aneurysm Patients
Sponsor:
Erasmus Medical Center
Organization:
Erasmus Medical Center
Study Overview
Official Title:
Study of Biomarker Profiling to Unravel the Intertwined Pathophysiology of Coronary Artery Disease and Abdominal Aortic Aneurysm
Status:
RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BIOMArCS-AAA
Brief Summary:
The BIOMArCS-AAA study aims to investigate the associations of temporal patterns of blood biomarkers with aneurysm growth in patients with abdominal aortic aneurysm AAA with particular attention to biomarkers that have demonstrated prognostic value for adverse disease outcomes in coronary artery disease and biomarkers for the main genetic pathways associated with AAA
Detailed Description:
BIOMArCS-AAA is an observational multicenter study Patients with an abdominal aortic aneurysm AAA will be recruited through the vascular surgery outpatient clinic of Erasmus MC and Maasstad Ziekenhuis the Netherlands The prospective longitudinal part of the study will include an arm with 120 AAA watchful waiting patients and an arm with 120 AAA patients undergoing endovascular aneurysm repair EVAR both with a 24-month follow-up period Clinical data collection and blood sampling will be conducted at baseline at 1 month after EVAR and at 6 12 18 and 24 months for all patients CT will be conducted at baseline and 12 and 24 months plus at 1 month in the EVAR patients Quality of life and depression questionnaires will be performed at baseline at 12 and 24 months of follow-up in all patients and at 1 month only in EVAR patients Additionally a cross-sectional study will be performed in 200 patients treated for AAA with EVAR in the past years In these patients clinical data collection blood sampling ultrasound and CT will be performed at their next regular outpatient clinic visit
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None