Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005475
Status:
COMPLETED
Last Update Posted:
2016-07-29
First Post:
2000-05-25
Brief Title:
Longitudinal Study of Asthma From Birth to Adulthood
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2009-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To extend follow-up of a birth cohort of asthmatic children through adolescence and on to adulthood
Detailed Description:
BACKGROUND
The population under study is the cohort from Tucson Childrens Respiratory Study CRS which began in 1980
DESIGN NARRATIVE
The longitudinal study follows a birth cohort of children initially established in the 1980s The study period took the children through their 16th birthday when a comprehensive respiratory and allergy assessment was conducted This extended follow-up took the cohort from birth to an age at which lung growth is virtually complete for girls and ending its most rapid phase for boys
The resulting data set was used to test diverse hypotheses concerned with lower respiratory tract illnesses LRI asthma wheezing allergy and smoking There were four broad areas 1 effects of LRI during the first three years of life and early and late symptoms and allergic sensitization on the picture of asthma 2 changes during adolescence in symptoms and airways responsiveness 3 the natural history of allergic sensitization and its relation to asthma and asthma-like symptoms and 4 the change in longitudinal lung function and factors affecting the change
A well documented data set was available to test these hypotheses LRI were documented during the first three years of life atopy was evaluated symptom status tracked and lung function periodically measured Infant lung function was assessed for a sample of the children and methacholine challenge was performed at age 11 In the evaluation at age 16 years symptoms lung function including methacholine responsiveness and atopy and lymphocyte phenotype were assessed Various methods for longitudinal data analysis were used
The study was renewed in 2001 to follow the birth cohort into early adulthood in order to generate data on the mechanisms and risk factors associated with asthma in early adult life Specifically the study will 1 identify factors that alter persistence and remission of asthma symptoms among young adults who developed asthma in childhood 2 assess the role of persistent eosinophilia during childhood as a mechanism which determines progression and incidence of asthma in early adult life and prevalence of persistent bronchial hyperresponsiveness BHR 3 measure noninvasive markers of airway inflammation in early adult life and identify correlates of these markers both with childhood and current asthma symptoms BHR and immune system indicators of allergy 4 predict early by age 20 decline in lung function with reference to childhood lower respiratory tract illnesses asthma-like symptoms and the initiation of smoking and 5 investigate the role of gender in incidence of and risk factors for asthma during adolescence and young adult life
The population under study is the cohort from Tucson Childrens Respiratory Study CRS which began in 1980
DESIGN NARRATIVE
The longitudinal study follows a birth cohort of children initially established in the 1980s The study period took the children through their 16th birthday when a comprehensive respiratory and allergy assessment was conducted This extended follow-up took the cohort from birth to an age at which lung growth is virtually complete for girls and ending its most rapid phase for boys
The resulting data set was used to test diverse hypotheses concerned with lower respiratory tract illnesses LRI asthma wheezing allergy and smoking There were four broad areas 1 effects of LRI during the first three years of life and early and late symptoms and allergic sensitization on the picture of asthma 2 changes during adolescence in symptoms and airways responsiveness 3 the natural history of allergic sensitization and its relation to asthma and asthma-like symptoms and 4 the change in longitudinal lung function and factors affecting the change
A well documented data set was available to test these hypotheses LRI were documented during the first three years of life atopy was evaluated symptom status tracked and lung function periodically measured Infant lung function was assessed for a sample of the children and methacholine challenge was performed at age 11 In the evaluation at age 16 years symptoms lung function including methacholine responsiveness and atopy and lymphocyte phenotype were assessed Various methods for longitudinal data analysis were used
The study was renewed in 2001 to follow the birth cohort into early adulthood in order to generate data on the mechanisms and risk factors associated with asthma in early adult life Specifically the study will 1 identify factors that alter persistence and remission of asthma symptoms among young adults who developed asthma in childhood 2 assess the role of persistent eosinophilia during childhood as a mechanism which determines progression and incidence of asthma in early adult life and prevalence of persistent bronchial hyperresponsiveness BHR 3 measure noninvasive markers of airway inflammation in early adult life and identify correlates of these markers both with childhood and current asthma symptoms BHR and immune system indicators of allergy 4 predict early by age 20 decline in lung function with reference to childhood lower respiratory tract illnesses asthma-like symptoms and the initiation of smoking and 5 investigate the role of gender in incidence of and risk factors for asthma during adolescence and young adult life
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL056177 | NIH | None | httpsreporternihgovquickSearchR01HL056177 |