Ignite Creation Date:
2024-05-05 @ 4:49 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00321568
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-05-03
Brief Title:
Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
An Exploratory Study on Detection of Cortical and White Matter Damage in Patients With Multiple Sclerosis Using Magnetic Resonance Imaging at 7 Tesla
Status:
COMPLETED
Status Verified Date:
2011-04-19
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will evaluate the ability of magnetic resonance imaging MRI using different magnet strengths 15 3 and 7 Tesla to detect damage in different parts of the brain in patients with multiple sclerosis The higher the Tesla the greater the ability to see brain changes Healthy subjects will also be studied to compare findings in patients with those of normal volunteers
Healthy normal volunteers and patients with multiple sclerosis 18-65 years of age may be eligible for this study Patients should have minimal clinical disability Candidates are screened with a medical history physical examination and blood and urine tests
Participants undergo three MRI examinations The first is on a 15 Tesla machine The second and third - at 3 Tesla and 7 Tesla - are done within 30 days of the first Each procedure takes about 2 hours Before and after the 7 Tesla examination subjects have an electrocardiogram EKG their blood pressure and temperature are measured and a blood sample is drawn
MRI uses a magnetic field and radio waves to produce images of body tissues and organs This test has several advantages over x-ray methods such as the ability to see more clearly inside the brain and to see chemical changes that might occur in specific neurological diseases Also since x-rays are not used there is no radiation risk Radio waves are generated and changes in magnetic fields are measured and analyzed by computer For the procedure the subject lies on a table that is moved into a metal cylinder the MRI scanner that has a strong magnetic field Earplugs are worn to muffle loud thumping noises caused by the electrical switching of the radio frequency circuits During the MRI subjects receive an injection of a contrast agent called Gadolinium which brightens the images
Healthy normal volunteers and patients with multiple sclerosis 18-65 years of age may be eligible for this study Patients should have minimal clinical disability Candidates are screened with a medical history physical examination and blood and urine tests
Participants undergo three MRI examinations The first is on a 15 Tesla machine The second and third - at 3 Tesla and 7 Tesla - are done within 30 days of the first Each procedure takes about 2 hours Before and after the 7 Tesla examination subjects have an electrocardiogram EKG their blood pressure and temperature are measured and a blood sample is drawn
MRI uses a magnetic field and radio waves to produce images of body tissues and organs This test has several advantages over x-ray methods such as the ability to see more clearly inside the brain and to see chemical changes that might occur in specific neurological diseases Also since x-rays are not used there is no radiation risk Radio waves are generated and changes in magnetic fields are measured and analyzed by computer For the procedure the subject lies on a table that is moved into a metal cylinder the MRI scanner that has a strong magnetic field Earplugs are worn to muffle loud thumping noises caused by the electrical switching of the radio frequency circuits During the MRI subjects receive an injection of a contrast agent called Gadolinium which brightens the images
Detailed Description:
OBJECTIVE Among the factors contributing to the poor identification of grey and white matter pathology of multiple sclerosis MS patients the low signal-to-noise ratio and consequential poor resolution of magnetic resonance imaging MRI obtained at conventional magnetic fields ie 15 Tesla play a significant role Preliminary results suggest that 7T-MRI has the capability to disclose characteristics of chronic white matter lesions heterogeneity in MS not seen at lower field MRI We now aim to extend those results by investigating whether lesions heterogeneous appearance pertain not only to chronic lesions ie those studied thus far but also to newly formed lesions ie those enhancing upon gadolinium injection The latter can be identified only by imaging at 7T with contrast injection those MS patients known to already have active lesions
STUDY POPULATION Up to 145 patients age range 18-65 range in the Expanded Disability Status Scale 0-45 with definite MS according to Poser criteria or other diseases of the central nervous system resembling MS from an imaging stand point and up to 120 agegender-matched healthy volunteers will be enrolled
DESIGN Patients previously shown to meet both the clinical and MRI criteria for MS and an equivalent number of gender- and age-matched healthy volunteers will be studied Initially both patients and healthy individuals will have conventional 15Tesla MRI T1-weighted scans without contrast whereas patients will also have post-contrast scans Next both groups of subjects will be imaged on both the 3 Tesla and 7 Tesla MRIs in a random order In each 3 Tesla and 7 Tesla MRI study the examination will include the following sequences 3 dimensional inversion-recovery-prepared fast spoiled gradient recalled images 3D-fluid-attenuated inversion recovery and double inversion recovery in addition to T1 and T2 conventional weighted images
A second group of 15 patients with or without clinical relapse who are known to be in an active stage of MS as seen by post-contrast MRI will be imaged Each patient may undergo a standard 3T MRI within the two weeks before the 7T MRI if needed as no information regarding hisher disease status are otherwise available from 3T MRI performed under other NIB protocols The former will allow ascertaining in advance hisher status of lesions activity thus providing an adequate number of patients with active lesions imaged at 7T Each patient may need to repeat hisher scan three times in case of magnetic instability during image acquisition Additional 3T and 7T MRIs will be performed after 1 and 6 months to follow active lesions evolution over time
A third group of patients with MS or any other disease of the central nervous system manifesting in magnetic resonance imaging with lesions of the white matter and grey matter which could mimic MS will be included Each patient will undergo a 3T MRI inclusive of post-contrast sequences as well as a 7T MRI
OUTCOME MEASURES The number of cortical lesions as well as white matter and deep grey abnormalities will be computed on images obtained at 15 3 and 7 Tesla MRIs The study will not aim at conducting a formal comparison of cortical or white matters lesions seen on 3 Tesla and 7 Tesla Instead the goal is to provide preliminary information that can be used to design a formal analysis of the sensitivities of the two platforms in studying those abnormalities seen in MS Active lesions found to be conspicuous upon contrast injection will be compared between T1 and gradient echo images at 7T Additionally the evolution of active lesions over time at 7T will be evaluated
STUDY POPULATION Up to 145 patients age range 18-65 range in the Expanded Disability Status Scale 0-45 with definite MS according to Poser criteria or other diseases of the central nervous system resembling MS from an imaging stand point and up to 120 agegender-matched healthy volunteers will be enrolled
DESIGN Patients previously shown to meet both the clinical and MRI criteria for MS and an equivalent number of gender- and age-matched healthy volunteers will be studied Initially both patients and healthy individuals will have conventional 15Tesla MRI T1-weighted scans without contrast whereas patients will also have post-contrast scans Next both groups of subjects will be imaged on both the 3 Tesla and 7 Tesla MRIs in a random order In each 3 Tesla and 7 Tesla MRI study the examination will include the following sequences 3 dimensional inversion-recovery-prepared fast spoiled gradient recalled images 3D-fluid-attenuated inversion recovery and double inversion recovery in addition to T1 and T2 conventional weighted images
A second group of 15 patients with or without clinical relapse who are known to be in an active stage of MS as seen by post-contrast MRI will be imaged Each patient may undergo a standard 3T MRI within the two weeks before the 7T MRI if needed as no information regarding hisher disease status are otherwise available from 3T MRI performed under other NIB protocols The former will allow ascertaining in advance hisher status of lesions activity thus providing an adequate number of patients with active lesions imaged at 7T Each patient may need to repeat hisher scan three times in case of magnetic instability during image acquisition Additional 3T and 7T MRIs will be performed after 1 and 6 months to follow active lesions evolution over time
A third group of patients with MS or any other disease of the central nervous system manifesting in magnetic resonance imaging with lesions of the white matter and grey matter which could mimic MS will be included Each patient will undergo a 3T MRI inclusive of post-contrast sequences as well as a 7T MRI
OUTCOME MEASURES The number of cortical lesions as well as white matter and deep grey abnormalities will be computed on images obtained at 15 3 and 7 Tesla MRIs The study will not aim at conducting a formal comparison of cortical or white matters lesions seen on 3 Tesla and 7 Tesla Instead the goal is to provide preliminary information that can be used to design a formal analysis of the sensitivities of the two platforms in studying those abnormalities seen in MS Active lesions found to be conspicuous upon contrast injection will be compared between T1 and gradient echo images at 7T Additionally the evolution of active lesions over time at 7T will be evaluated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06-N-0154 | None | None | None |