Ignite Creation Date:
2024-05-06 @ 12:09 PM
Last Modification Date:
2024-10-26 @ 12:55 PM
Study NCT ID:
NCT03694028
Status:
COMPLETED
Last Update Posted:
2022-10-04
First Post:
2018-09-29
Brief Title:
Neuromuscular and Biomechanical Control of Lower Limb Loading in Individuals With Chronic Stroke
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Neuromuscular and Biomechanical Control of Lower Limb Loading in Individuals With Chronic Stroke
Status:
COMPLETED
Status Verified Date:
2022-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Stroke is the leading cause of long-term disability in the US Individuals with hemiparesis due to stroke often have difficulty bearing weight on their legs and transferring weight from one leg to the other The ability to bear weight on the legs is important during functional movements such as rising from a chair standing and walking Diminished weight transfer contributes to asymmetries during walking which commonly leads to greater energy expenditure Moreover deficits in bearing weight on the paretic leg contribute to lateral instability and are associated with decreased walking speed and increased risk of falling in individuals post-stroke These functional limitations affect community participation and life quality Thus restoring the ability to bear weight on the legs ie limb loading is a critical goal for rehabilitation post-stroke The purpose of this research is to identify the impairments in neuromechanical mechanisms of limb loading and determine whether limb loading responses can be retrained by induced forced limb loading
Detailed Description:
Stroke is the leading cause of long-term disability in the US Individuals with hemiparesis due to stroke often have difficulty bearing weight on the paretic lower extremity and transferring weight from one leg to the other Impaired weight transfer and limb loading contribute to lateral instability and are associated with decreased walking speed and increased risk of falling Consequently restoring limb loading ability is an important goal for rehabilitation post-stroke Despite considerable rehabilitation efforts aimed at enhancing paretic limb loading their effectiveness on improving neuromotor and functional outcomes remains limited possibly due to poorly understood limb loading mechanisms and the reluctance to use the paretic limb The coordination of neuromuscular actions to regulate loading force during weight acceptance is an important component of functional limb loading Because altered neuromuscular control is common in persons with stroke it is possible that these abnormalities may impair limb loading ability The long-term objective of this project is to develop a mechanism-based framework for designing and testing the effectiveness of novel rehabilitation interventions to enhance lower limb weight transfer and limb loading to improve balance and mobility This project aims to 1 identify the neuromuscular and biomechanical abnormalities in limb loading responses in individuals post-stroke 2 determine the underlying mechanisms responsible for the deficits in limb loading and 3 test the short-term effectiveness of a 6-week perturbation-induced limb load training program on improving limb loading responses and mobility function The investigators propose to apply a sudden unilateral lowering of the supporting surface to induce lateral weight transfer that forces limb loading Kinetic kinematic and lower extremity muscle activation patterns will be recorded The investigators expect that compared to healthy controls individuals with stroke will show increased muscle co-activation of the knee musculature with decreased knee flexion and torque production and irregular impact force regulation during loading that will disrupt weight transfer and loading of the paretic limb Furthermore the investigators hypothesize that compared to a conventional clinical weight-shift rehabilitation training program the imposed limb loading group will show greater improvements during voluntary stepping and walking following training Specifically the investigators expect the knee muscle co-activation duration will be reduced with increased knee joint torque and the paretic single stancedouble support time will increase reflecting improved paretic limb loading ability during gait following training
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None