Ignite Creation Date:
2024-05-06 @ 12:08 PM
Last Modification Date:
2024-10-26 @ 12:54 PM
Study NCT ID:
NCT03681080
Status:
COMPLETED
Last Update Posted:
2023-06-26
First Post:
2018-09-10
Brief Title:
Concentration and Attentional Deficits in POTS and Other Autonomic Neuropathies
Sponsor:
RWTH Aachen University
Organization:
RWTH Aachen University
Study Overview
Official Title:
Understanding Impaired Concentration Attentional Deficits and Their Pathophysiology in Postural Orthostatic Tachycardia Syndrome POTS and Other Autonomic Neuropathies POTSKog-Study Aachen
Status:
COMPLETED
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
POTSKog
Brief Summary:
People with POTS autoimmune autonomic neuropathy AAN pure autonomic failure PAF SFN and Ehlers Danlos Syndrome EDS do not only suffer from orthostatic symptoms such as dizziness headache neck pain blurred vision or pre- syncope They also experience deficits in attention and concentration more precisely deficits in selective perspective operating speed executive functions and memory performance mainly in upright position Only few studies concerning cognitive impairment in autonomic neuropathies their frequency aetiology and therapy exist Many patients concerned especially with POTS report attention deficits and brain fog with problems in their everyday life and work predominantly in upright posture Specific symptomatic or medical therapies do not exist Medical treatment with Modafinil is discussed and part of a current study at Vanderbilt Autonomic Dysfunction Centre 1-5 The investigators want to investigate if problems of concentration attention andor cognitive dysfunction exist in people with POTS AAN SFN and EDS compared to healthy controls HC Thus the investigators use detailed clinical autonomic and neuropsychological tests in different body positions lying sitting and standing as also acute therapy leg crossing
Detailed Description:
We are still recruting healthy controls and patients with autoimmune autonomic neuropathy in order to perform titl table examination and laboratory testing on day one ono an empty stomach without morning medication Cognitive testing is performed on day two after randomization in three groups lying standing and standing with legs crossed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None