Ignite Creation Date:
2024-05-06 @ 12:07 PM
Last Modification Date:
2024-10-26 @ 12:55 PM
Study NCT ID:
NCT03688698
Status:
COMPLETED
Last Update Posted:
2018-09-28
First Post:
2018-03-26
Brief Title:
PETMRI in PAH Patients
Sponsor:
Medical University of Bialystok
Organization:
Medical University of Bialystok
Study Overview
Official Title:
The Relationship Between Myocardial 18F-FDG Uptake and Right Ventricular Coupling Obtained by PETMRI Hybrid Imaging in Patients With Pulmonary Arterial Hypertension
Status:
COMPLETED
Status Verified Date:
2018-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aim of the study is to compare novel parameters of right ventricle RV function from right heart catheterization RHC and magnetic resonance imaging MRI with PET-derived RV FDG uptake
Detailed Description:
Objectives In pilot study investigators aimed to compare novel parameters of right ventricle RV function from right heart catheterization RHC and magnetic resonance imaging MRI with PET-derived RV FDG uptake
Background Right ventricular RV function is a major determinant of survival in patients with pulmonary arterial hypertension PAH Hemodynamic parameters like end-systolic elastance Ees arterial elastance Ea pulmonary arterial compliance PAC and EesEa ratio have been shown to reflect RV function and prognosis in PAH Increased RV 18F-fluoro-2-deoxyglucose FDG uptake in positron emission tomography PET was recently associated with progressive RV dysfunction in these patients
Methods Twenty-five stable PAH patients 49921594 years and twelve healthy subjects control group 44751351 years had simultaneous PET and MRI scans performed FDG was used as a tracer and its uptake was presented as a standardized uptake value SUV for both left LV and right ventricle
Background Right ventricular RV function is a major determinant of survival in patients with pulmonary arterial hypertension PAH Hemodynamic parameters like end-systolic elastance Ees arterial elastance Ea pulmonary arterial compliance PAC and EesEa ratio have been shown to reflect RV function and prognosis in PAH Increased RV 18F-fluoro-2-deoxyglucose FDG uptake in positron emission tomography PET was recently associated with progressive RV dysfunction in these patients
Methods Twenty-five stable PAH patients 49921594 years and twelve healthy subjects control group 44751351 years had simultaneous PET and MRI scans performed FDG was used as a tracer and its uptake was presented as a standardized uptake value SUV for both left LV and right ventricle
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None