Ignite Creation Date:
2024-05-06 @ 12:05 PM
Last Modification Date:
2024-10-26 @ 12:54 PM
Study NCT ID:
NCT03670186
Status:
UNKNOWN
Last Update Posted:
2018-09-13
First Post:
2018-09-05
Brief Title:
Effects of Genetic Variation on the Efficacy of Aerobic Exercise
Sponsor:
McMaster University
Organization:
McMaster University
Study Overview
Official Title:
Effects of BDNF Val66Met Polymorphism on the Efficacy of Aerobic Exercise in Sedentary Healthy Males
Status:
UNKNOWN
Status Verified Date:
2018-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study investigates whether after six weeks of exercise a genetic variant Val66Met in the gene that makes a molecule BDNF important for brain health and function influences the beneficial effects of a further session of exercise in sedentary healthy males The aim of this research is to determine whether not having this genetic variant Val66Met provides an advantage for achieving greater exercise-induced benefits After six consecutive weeks of exercise high-intensity interval training HIIT three times per week the effects of a further session of exercise on brain activity are studied in healthy sedentary males with and without the BDNF genetic variant Further whether the BDNF genetic variant impacts the effects of six weeks of aerobic exercise on blood BDNF levels memory and cardiorespiratory fitness is examined This data will help to understand whether genetic factors moderate the beneficial effects of exercise Understanding what factors influence the effectiveness of exercise training programs is essential to individualize exercise programs and maximize their positive effects on the brain and during rehabilitation following brain injuries
Detailed Description:
Aerobic exercise promotes brain health and function Indeed exercise has been shown to improve learning and memory delay cognitive decline and protect against brain atrophy in healthy aging individuals Additionally exercise programs reduce brain injury and delay onset and progression of neurodegenerative diseases such as Alzheimers However individual variability in the efficacy of these programs limit their widespread application as a therapeutic Genetic variants may contribute to the large degree of individual variability in the effects of exercise on cognition and brain health
Brain-derived neurotrophic factor BDNF is a neurotrophin that plays a key role in activity-dependent neuroplasticity Rodent studies show that increases in BDNF mediate the effects of exercise on learning and memory A single nucleotide polymorphism in the BDNF gene that causes a valine Val to methionine Met substitution at codon 66 reduces activity-dependent secretion of BDNF and is associated with altered hippocampal activation and poorer episodic memory The objective of this research is to determine whether after six consecutive weeks of high-intensity interval training HIIT three times per week BDNF Val66Met polymorphism impacts the effects of a further HIIT session on corticospinal excitability as well as intracortical and spinal circuitry Additionally this study aims to assess whether BDNF Val66Met polymorphism moderates the effects of six consecutive weeks of HIIT on BDNF working memory and cardiorespiratory fitness levels The findings will indicate whether the BDNF Val allele provides an advantage for achieving greater exercise-induced benefits and could thus help individualize exercise programs to maximize their beneficial effects These data will also provide insights into the mechanisms by which aerobic exercise induces neuroplasticity
Brain-derived neurotrophic factor BDNF is a neurotrophin that plays a key role in activity-dependent neuroplasticity Rodent studies show that increases in BDNF mediate the effects of exercise on learning and memory A single nucleotide polymorphism in the BDNF gene that causes a valine Val to methionine Met substitution at codon 66 reduces activity-dependent secretion of BDNF and is associated with altered hippocampal activation and poorer episodic memory The objective of this research is to determine whether after six consecutive weeks of high-intensity interval training HIIT three times per week BDNF Val66Met polymorphism impacts the effects of a further HIIT session on corticospinal excitability as well as intracortical and spinal circuitry Additionally this study aims to assess whether BDNF Val66Met polymorphism moderates the effects of six consecutive weeks of HIIT on BDNF working memory and cardiorespiratory fitness levels The findings will indicate whether the BDNF Val allele provides an advantage for achieving greater exercise-induced benefits and could thus help individualize exercise programs to maximize their beneficial effects These data will also provide insights into the mechanisms by which aerobic exercise induces neuroplasticity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None