Ignite Creation Date:
2024-05-05 @ 4:48 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00316823
Status:
COMPLETED
Last Update Posted:
2014-02-24
First Post:
2006-04-19
Brief Title:
Genetic Analysis in Diagnosing Thyroid Cancer in Patients With Thyroid Nodules
Sponsor:
University of California San Francisco
Organization:
National Cancer Institute NCI
Study Overview
Official Title:
Gene Expression Analysis in Thyroid Nodule FNA Samples
Status:
COMPLETED
Status Verified Date:
2008-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
RATIONALE Finding genetic markers for thyroid cancer in a biopsy specimen may help doctors diagnose thyroid cancer
PURPOSE This clinical trial is studying how well genetic analysis works in diagnosing thyroid cancer in patients with thyroid nodules
PURPOSE This clinical trial is studying how well genetic analysis works in diagnosing thyroid cancer in patients with thyroid nodules
Detailed Description:
OBJECTIVES
Evaluate the diagnostic accuracy of biomarkers and mRNA expression analysis using fine-needle aspiration FNA biopsy samples from patients with thyroid nodules
Correlate the level of gene expression with the aggressiveness of differentiated thyroid cancer in FNA biopsy samples
OUTLINE Patients undergo fine-needle aspiration FNA biopsy as part of routine care Additional thyroid tissue is collected during the biopsy for gene expression analysis Patients who have already had a biopsy undergo FNA biopsy during thyroidectomy
Tissue samples will be examined for gene expression by reverse transcriptase-polymerase chain reaction PCR real-time quantitative PCR and immunohistochemistry
PROJECTED ACCRUAL A total of 400 patients will be accrued for this study
Evaluate the diagnostic accuracy of biomarkers and mRNA expression analysis using fine-needle aspiration FNA biopsy samples from patients with thyroid nodules
Correlate the level of gene expression with the aggressiveness of differentiated thyroid cancer in FNA biopsy samples
OUTLINE Patients undergo fine-needle aspiration FNA biopsy as part of routine care Additional thyroid tissue is collected during the biopsy for gene expression analysis Patients who have already had a biopsy undergo FNA biopsy during thyroidectomy
Tissue samples will be examined for gene expression by reverse transcriptase-polymerase chain reaction PCR real-time quantitative PCR and immunohistochemistry
PROJECTED ACCRUAL A total of 400 patients will be accrued for this study
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| UCSF-05205 | None | None | None |
| UCSF-H28355-27029-01 | None | None | None |