Ignite Creation Date:
2024-05-06 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 12:53 PM
Study NCT ID:
NCT03660397
Status:
UNKNOWN
Last Update Posted:
2018-09-06
First Post:
2018-06-07
Brief Title:
Adrenal Artery Ablation for Uncontrolled Hypertension
Sponsor:
Third Military Medical University
Organization:
Third Military Medical University
Study Overview
Official Title:
Efficacy and Safety of Adrenal Artery AblationAAAin the Treatment of Uncontrolled Hypertension A Randomized Parallel Active-controlled Clinical Trial
Status:
UNKNOWN
Status Verified Date:
2018-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The activation of the renin-angiotensin-aldosterone system RAAS plays a key role in uncontrolled hypertension or resistant hypertension Surgery and and medicine are the main treatment for primary aldosteronismPA by the current guidelines However only a small part of patients with PA meet the surgical criteria and most of patients with uncontrolled hypertension and activation of RAAS have to take spironolactone or other antihypertensive drugs for long time On the other side long-term inhibition of aldosterone receptor may cause hyperkalemia male breast hyperplasia and other adverse reactions Moreover hyperaldosterone is still not corrected by spironolactone which causes extensive cerebrovascular damages even though blood pressure and blood potassium had been normalized
With the development of adrenal vein sampling and adrenal ablation selective arterial ablation of adrenal glandAAA was observed with significant decrease of blood aldosterone and blood pressure in patients with PA which made it promising that uncontrolled hypertension could be relieved by selective AAA
With the development of adrenal vein sampling and adrenal ablation selective arterial ablation of adrenal glandAAA was observed with significant decrease of blood aldosterone and blood pressure in patients with PA which made it promising that uncontrolled hypertension could be relieved by selective AAA
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None