Ignite Creation Date:
2024-05-06 @ 12:03 PM
Last Modification Date:
2024-10-26 @ 12:53 PM
Study NCT ID:
NCT03666039
Status:
COMPLETED
Last Update Posted:
2022-07-19
First Post:
2018-09-04
Brief Title:
Reversing Maladaptive Reorganization in Frail Brains
Sponsor:
Central Institute of Mental Health Mannheim
Organization:
Central Institute of Mental Health Mannheim
Study Overview
Official Title:
Reversing Maladaptive Reorganization in Frail Brains Sensorimotor Training Brain Plasticity and the Role of Brain-derived Neurotrophic Factor
Status:
COMPLETED
Status Verified Date:
2022-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FRAILBRAIN
Brief Summary:
Neuroscientific models of maladaptive aging emphasize the loss of sensorimotor stimulation and reduced modulatory capacities as core processes in the development of maladaptive plastic changes of the brain and subsequent cognitive and bodily decline as determinants of frailty and multimorbidity in old age The investigators plan to analyze anatomical neurophysiological and neuropsychological correlates of maladaptive plasticity in frail persons and plan to test how innovative interventions that target maladaptive plasticity alter brain function and neurocognitive skills There are novel interventions that have been shown to target the neurocognitive deficits and enhance plasticity in brain areas that are affected first in the progress of aging Specifically sensory training has been employed to enhance relevant input to the brain and to improve neuromodulatory function and has yielded high effect sizes The investigators will perform proof of concept studies to examine the utility of sensorimotor training and examine the role of brain-derived neurotrophic growth factor to enhance brain plasticity and memory functions as well as their transfer to other cognitive domains The investigators will implement motivational enhancement strategies using virtual reality in these treatments that can further boost training effects and plasticity but have not been employed in these treatments so far Biomarkers for the remediation of maladaptive changes will involve neuropsychological assessments brain imaging brain-derived neurotrophic factor BDNF levels and BDNF genotype Thus the investigators will be able to comprehensively characterize dysfunctional plasticity and the specific mechanisms of the interventions that are employed and investigate innovative clinical trials
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None