Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005137
Status:
COMPLETED
Last Update Posted:
2014-05-29
First Post:
2000-05-25
Brief Title:
Heritage Study--Genetics Exercise and Risk Factors
Sponsor:
Washington University School of Medicine
Organization:
Washington University School of Medicine
Study Overview
Official Title:
Health Risk Factors Exercise Training and Genetics
Status:
COMPLETED
Status Verified Date:
2014-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HERITAGE
Brief Summary:
To document the role of the genotype in the cardiovascular and metabolic responses to aerobic exercise-training and the contribution of inherited factors in the changes brought about by regular exercise for several cardiovascular disease and diabetes risk factors A consortium of laboratories from five institutions in the United States and Canada are carrying out this study
Detailed Description:
BACKGROUND
This research should increase our understanding of human variation the genetics of adaptation to exercise-training and of the concomitant changes in cardiovascular disease and diabetes risk factors
DESIGN NARRATIVE
A total of 742 sedentary subjects were recruited initially tested exercise-trained in the laboratory with the same program for 20 weeks and re-tested The subjects came from families of Caucasian descent with both parents and three biological adult offspring and families of African-American ancestry Oxygen uptake expiratory volume and respiratory exchange ratio blood pressure heart rate blood lactate glucose glycerol and free-fatty acids stroke volume and cardiac output were measured during exercise before and after training and maximal oxygen uptake was determined Plasma lipids lipoproteins and apoproteins glucose tolerance and insulin response to an intravenous glucose load plasma sex steroids and glucocorticoids resting systolic and diastolic blood pressures and body fat and regional fat distribution were also assessed Dietary habits level of habitual physical activity and other lifestyle components were assessed by questionnaires Genetic analyses included the determination of the heritability level for each phenotype and its response to regular exercise testing for the presence of paternal or maternal effects sex-limited effects major gene effects and segregation patterns Multivariate genetic analyses and complex segregation analyses were used to develop hypotheses concerning the genetic basis of the response to exercise-training
The study was renewed in September 1997 to perform analyses of the data collected under Phase I A series of nongenetic studies were undertaken on the dataset Physiological behavioral and social determinants of maximal and submaximal indicators of cardiorespiratory endurance in the sedentary state and in the response to training were investigated taking into account the contributions of age gender and race Similar analyses were conducted on the cardiovascular disease and non-insulin dependent diabetes mellitus NIDDM risk factors monitored in the study Genetic analyses determined the heritability levels and tested for paternal or maternal effects major gene effects and segregation patterns which were used to develop hypotheses concerning genetic bases of the response to endurance exercise A panel of candidate genes were typed and used for association and linkage studies Differential display analysis of skeletal muscle transcripts were used to identify new candidate genes for the response to endurance exercise Finally a genome wide search was undertaken to isolate candidate genomic regions and positional candidate genes for the response of cardiorespiratory endurance and cardiovascular and NIDDM risk factor phenotypes
The study was renewed in 2001 for four years to continue analyses of the data
This research should increase our understanding of human variation the genetics of adaptation to exercise-training and of the concomitant changes in cardiovascular disease and diabetes risk factors
DESIGN NARRATIVE
A total of 742 sedentary subjects were recruited initially tested exercise-trained in the laboratory with the same program for 20 weeks and re-tested The subjects came from families of Caucasian descent with both parents and three biological adult offspring and families of African-American ancestry Oxygen uptake expiratory volume and respiratory exchange ratio blood pressure heart rate blood lactate glucose glycerol and free-fatty acids stroke volume and cardiac output were measured during exercise before and after training and maximal oxygen uptake was determined Plasma lipids lipoproteins and apoproteins glucose tolerance and insulin response to an intravenous glucose load plasma sex steroids and glucocorticoids resting systolic and diastolic blood pressures and body fat and regional fat distribution were also assessed Dietary habits level of habitual physical activity and other lifestyle components were assessed by questionnaires Genetic analyses included the determination of the heritability level for each phenotype and its response to regular exercise testing for the presence of paternal or maternal effects sex-limited effects major gene effects and segregation patterns Multivariate genetic analyses and complex segregation analyses were used to develop hypotheses concerning the genetic basis of the response to exercise-training
The study was renewed in September 1997 to perform analyses of the data collected under Phase I A series of nongenetic studies were undertaken on the dataset Physiological behavioral and social determinants of maximal and submaximal indicators of cardiorespiratory endurance in the sedentary state and in the response to training were investigated taking into account the contributions of age gender and race Similar analyses were conducted on the cardiovascular disease and non-insulin dependent diabetes mellitus NIDDM risk factors monitored in the study Genetic analyses determined the heritability levels and tested for paternal or maternal effects major gene effects and segregation patterns which were used to develop hypotheses concerning genetic bases of the response to endurance exercise A panel of candidate genes were typed and used for association and linkage studies Differential display analysis of skeletal muscle transcripts were used to identify new candidate genes for the response to endurance exercise Finally a genome wide search was undertaken to isolate candidate genomic regions and positional candidate genes for the response of cardiorespiratory endurance and cardiovascular and NIDDM risk factor phenotypes
The study was renewed in 2001 for four years to continue analyses of the data
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL047317 | NIH | None | httpsreporternihgovquickSearchR01HL047317 |