Ignite Creation Date:
2024-05-06 @ 12:02 PM
Last Modification Date:
2024-10-26 @ 12:53 PM
Study NCT ID:
NCT03663062
Status:
COMPLETED
Last Update Posted:
2020-11-04
First Post:
2017-12-15
Brief Title:
ObeSity Related Colorectal Adenoma Risk
Sponsor:
South Tyneside and Sunderland NHS Foundation Trust
Organization:
South Tyneside and Sunderland NHS Foundation Trust
Study Overview
Official Title:
ObeSity Related Colorectal Adenoma Risk
Status:
COMPLETED
Status Verified Date:
2018-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
OSCAR
Brief Summary:
In the UK around 1 in 16 men and 1 in 20 women will develop bowel cancer at some point in their lives Most bowel cancers happen when a type of growth in the bowel called an adenoma eventually becomes cancerous Cutting out adenomas reduces the risk of developing bowel cancer
Certain people are more likely to have adenomas than others for example people who are overweight People who are overweight are also more likely to develop liver disease by laying too much fat down in the liver Studies in Asia have shown that people with fatty liver disease are more likely to have adenomas and these are more commonly found in the part of the bowel right colon furthest from the bottom end
Information on the link between obesity fatty liver disease and adenomas is very limited particularly in the Western population
The investigators will assess the link between body weight fatty liver and adenomas in the UK population 1430 patients will be invited some through the bowel cancer screening programme and some with symptoms such as low blood count bleeding or changed bowel habit These patients will already have been referred for a camera test looking into the bowel called a colonoscopy Information including height weight and some health questions will be taken Blood samples will be taken The investigators will compare the number of patients with adenomas who have liver disease or who are overweight with those who dont This information will be used to develop a scoring system to predict risk of adenomas This will help the investigators to decide if undertaking colonoscopies in these patients will identify those at increased risk of bowel cancer
Certain people are more likely to have adenomas than others for example people who are overweight People who are overweight are also more likely to develop liver disease by laying too much fat down in the liver Studies in Asia have shown that people with fatty liver disease are more likely to have adenomas and these are more commonly found in the part of the bowel right colon furthest from the bottom end
Information on the link between obesity fatty liver disease and adenomas is very limited particularly in the Western population
The investigators will assess the link between body weight fatty liver and adenomas in the UK population 1430 patients will be invited some through the bowel cancer screening programme and some with symptoms such as low blood count bleeding or changed bowel habit These patients will already have been referred for a camera test looking into the bowel called a colonoscopy Information including height weight and some health questions will be taken Blood samples will be taken The investigators will compare the number of patients with adenomas who have liver disease or who are overweight with those who dont This information will be used to develop a scoring system to predict risk of adenomas This will help the investigators to decide if undertaking colonoscopies in these patients will identify those at increased risk of bowel cancer
Detailed Description:
Bowel cancer or colorectal cancer CRC is the second most common cancer affecting both men and women in England The majority of CRCs develop from a pre-cancerous type of growth in the bowel called an adenoma Detecting and removing these adenomas is important in reducing CRC risk A study which undertook a once-off camera examination of the left hand side of the bowel flexible sigmoidoscopy removing any adenomas demonstrated a reduction in CRC by 23 and reduced mortality by 31
Although a single cause for adenomas is not known several factors can predispose patients to adenomas including age gender family history cigarette smoking and excess body weight EBW
Obesity is becoming an increasing problem in the UK with approximately a quarter of adults classed as obese in England Patients who are obese are at higher risk of having adenomas Studies have shown that patients with EBW are more likely to have fatty disease of the liver non-alcoholic fatty liver disease NAFLD by laying down fat in the liver Studies in Asia have shown that patients with NAFLD are more likely to have adenomas and that these are more likely to be in the right side of the bowel which is furthest from the anus right colon Although these studies have shown a link between NAFLD and adenomas they have all used invasive or expensive markers of fatty liver disease No study has correlated the link between liver enzymes blood tests and adenomas or by using scoring systems to determine the presence or absence of significant fatty liver disease Furthermore no Western studies have confirmed the link between NAFLD and adenomas meaning it is unclear whether this link is only present in the Asian population
Approximately 400000 colonoscopies camera examinations of the large bowel are performed each year within the NHS for the investigation of gastrointestinal symptoms including altered bowel habit rectal bleeding and low blood count When polyps are found patients often have a follow-up surveillance colonoscopy to check that no new adenomas have formed The timing and need for surveillance is based only on the number and size of adenomas found and does not take into account any risk factors which the patient may have
The NHS Bowel Cancer Screening Programme BCSP invites all individuals aged 60-74 to undertake a stool sample test which looks for blood called faecal occult blood testing FOBt every two years Those who have a positive FOBt are then invited for a colonoscopy This programme is purely based on age and is not targeted Another arm of the BCSP was introduced in 2013 where all individuals aged 55 are invited for a flexible sigmoidoscopy and removal of adenomas Anyone who is felt to be high risk according to the number or size of adenomas then undergoes a colonoscopy
The BCSP has led to cancers being detected at an earlier stage but is not protecting the population against cancers in the right side of the bowel
In summary although studies in Asian populations have suggested an association between NAFLD and colorectal adenomas this has not been repeated in a Western population It is important that the association is explored further in a Western population in a simple non-invasive manner Assessing markers of NAFLD and a wider range of risk factors for adenomas will allow us to develop a tool to predict which patients are at increased risk of adenomas called a risk model
The OSCAR study is a multicentre observational study has been designed which will recruit 1430 participants from nine sites eight in the North of England who are all members of the Northern Region Endoscopy Group NREG and one from Kettering General Hospital NHS Trust NREG is an endoscopy research collaborative group with an excellent track record of delivering similar endoscopy based research studies to time and target Participation will involve collecting information relating to obesity and fatty liver disease in patients already attending for colonoscopy in addition to collecting information about the number and size of any adenomas found
All patients scheduled for colonoscopy will be provided with an invitation letter and patient information sheet in addition with the standard information about the colonoscopy procedure that the endoscopy unit provides As colonoscopy requires a period of preparation prior to the test patients will receive this information at least 24 hours before the procedure allowing ample time to consider the study before attending the endoscopy department
Taking part in this study will change very little about the patients experience of the colonoscopy test itself If the patient agrees to take part in this study the information sheet will be reviewed with them by a research team member an opportunity to ask questions given and the consent form signed Eligibility to take part in the study will be checked and the patient will be weighed have their height checked waist circumference measured body mass index BMI calculated and blood pressure checked A research team member will undertake a health questionnaire which will include the following items
1 Current and previous smoking history
2 Current and previous alcohol history
3 Current medications including Aspirin Statin Insulin non-steroidal anti-inflammatory drugs NSAIDs Diabetic medication antibiotics and others
4 Family history of colorectal cancer
5 Family history of ischaemic heart disease in a first degree relative under the age of 60
6 History of liver disease
7 History of hypertension
8 History of diabetes- Type I Type II
9 History of chronic kidney disease Stage 45
10 History of atrial fibrillation
11 History of rheumatoid arthritis
12 Personal history of anti-obesity surgery
These will be entered onto the case report form CRF
An intravenous cannula a thin plastic tube which is inserted into a vein in the arm is then inserted as part of routine care before the colonoscopy procedure Blood tests will be taken from this at the time of insertion to prevent the need for a separate blood test These tests will include
1 Bilirubin
2 Alanine aminotransferase ALT
3 Alkaline phosphatase ALP
4 Aspartate aminotransferase AST
5 Gamma-glutamyl transferase GGT
6 Full blood count FBC
7 HbA1c
8 Fasting blood glucose
9 Lipids Cholesterol HDL and Triglycerides
10 Albumin
11 Immunoglobulin A
Patients will also need to sign a separate consent form for the colonoscopy procedure itself as part of routine practice
The patient will then enter the procedure room as per usual practice for their colonoscopy During the procedure the research team member will record data onto the CRF procedural data findings at colonoscopy etc The colonoscopy report will be generated as per the usual practice in each unit
A subset of patients will undergo Fibroscan which is a non-invasive test to evaluate for liver fibrosis to explore the association between the presence of colorectal adenomaCRC and the presence of liver fibrosis
After the procedure the patient will enter the recovery ward and follow usual practice in the unit Although participants will remain in the study for 14 days to allow data collection and to follow-up any abnormal results participants will not require any further visits and the majority will not be contacted by the research team If a new abnormality is found on checking blood samples the patient will be contacted by a member of the research team and advised to make an appointment with their General Practitioner GP
Statistical analysis will be undertaken by Professor Steven Rushton Professor of Biological Modelling at Newcastle University
The primary outcome of this study is to develop a risk model which can be used to inform colorectal neoplasia screening and surveillance guidelines and to inform a future study targeting screening of higher risk individuals
The secondary outcomes will support this model by identifying which demographics contribute to increased predisposition to colorectal neoplasia namely smoking history alcohol intake and obesity measured by BMI and waist circumference The investigators also aim to assess whether the presence or degree of liver fibrosis as measured by FIB4 score and Fibroscan affects the risk of colorectal neoplasia and by exploring the link between NAFLD obesity and colorectal neoplasia in terms of adenoma burden site and histological features Lastly the association between abnormal liver enzymes and colorectal neoplasia will be explored
Although a single cause for adenomas is not known several factors can predispose patients to adenomas including age gender family history cigarette smoking and excess body weight EBW
Obesity is becoming an increasing problem in the UK with approximately a quarter of adults classed as obese in England Patients who are obese are at higher risk of having adenomas Studies have shown that patients with EBW are more likely to have fatty disease of the liver non-alcoholic fatty liver disease NAFLD by laying down fat in the liver Studies in Asia have shown that patients with NAFLD are more likely to have adenomas and that these are more likely to be in the right side of the bowel which is furthest from the anus right colon Although these studies have shown a link between NAFLD and adenomas they have all used invasive or expensive markers of fatty liver disease No study has correlated the link between liver enzymes blood tests and adenomas or by using scoring systems to determine the presence or absence of significant fatty liver disease Furthermore no Western studies have confirmed the link between NAFLD and adenomas meaning it is unclear whether this link is only present in the Asian population
Approximately 400000 colonoscopies camera examinations of the large bowel are performed each year within the NHS for the investigation of gastrointestinal symptoms including altered bowel habit rectal bleeding and low blood count When polyps are found patients often have a follow-up surveillance colonoscopy to check that no new adenomas have formed The timing and need for surveillance is based only on the number and size of adenomas found and does not take into account any risk factors which the patient may have
The NHS Bowel Cancer Screening Programme BCSP invites all individuals aged 60-74 to undertake a stool sample test which looks for blood called faecal occult blood testing FOBt every two years Those who have a positive FOBt are then invited for a colonoscopy This programme is purely based on age and is not targeted Another arm of the BCSP was introduced in 2013 where all individuals aged 55 are invited for a flexible sigmoidoscopy and removal of adenomas Anyone who is felt to be high risk according to the number or size of adenomas then undergoes a colonoscopy
The BCSP has led to cancers being detected at an earlier stage but is not protecting the population against cancers in the right side of the bowel
In summary although studies in Asian populations have suggested an association between NAFLD and colorectal adenomas this has not been repeated in a Western population It is important that the association is explored further in a Western population in a simple non-invasive manner Assessing markers of NAFLD and a wider range of risk factors for adenomas will allow us to develop a tool to predict which patients are at increased risk of adenomas called a risk model
The OSCAR study is a multicentre observational study has been designed which will recruit 1430 participants from nine sites eight in the North of England who are all members of the Northern Region Endoscopy Group NREG and one from Kettering General Hospital NHS Trust NREG is an endoscopy research collaborative group with an excellent track record of delivering similar endoscopy based research studies to time and target Participation will involve collecting information relating to obesity and fatty liver disease in patients already attending for colonoscopy in addition to collecting information about the number and size of any adenomas found
All patients scheduled for colonoscopy will be provided with an invitation letter and patient information sheet in addition with the standard information about the colonoscopy procedure that the endoscopy unit provides As colonoscopy requires a period of preparation prior to the test patients will receive this information at least 24 hours before the procedure allowing ample time to consider the study before attending the endoscopy department
Taking part in this study will change very little about the patients experience of the colonoscopy test itself If the patient agrees to take part in this study the information sheet will be reviewed with them by a research team member an opportunity to ask questions given and the consent form signed Eligibility to take part in the study will be checked and the patient will be weighed have their height checked waist circumference measured body mass index BMI calculated and blood pressure checked A research team member will undertake a health questionnaire which will include the following items
1 Current and previous smoking history
2 Current and previous alcohol history
3 Current medications including Aspirin Statin Insulin non-steroidal anti-inflammatory drugs NSAIDs Diabetic medication antibiotics and others
4 Family history of colorectal cancer
5 Family history of ischaemic heart disease in a first degree relative under the age of 60
6 History of liver disease
7 History of hypertension
8 History of diabetes- Type I Type II
9 History of chronic kidney disease Stage 45
10 History of atrial fibrillation
11 History of rheumatoid arthritis
12 Personal history of anti-obesity surgery
These will be entered onto the case report form CRF
An intravenous cannula a thin plastic tube which is inserted into a vein in the arm is then inserted as part of routine care before the colonoscopy procedure Blood tests will be taken from this at the time of insertion to prevent the need for a separate blood test These tests will include
1 Bilirubin
2 Alanine aminotransferase ALT
3 Alkaline phosphatase ALP
4 Aspartate aminotransferase AST
5 Gamma-glutamyl transferase GGT
6 Full blood count FBC
7 HbA1c
8 Fasting blood glucose
9 Lipids Cholesterol HDL and Triglycerides
10 Albumin
11 Immunoglobulin A
Patients will also need to sign a separate consent form for the colonoscopy procedure itself as part of routine practice
The patient will then enter the procedure room as per usual practice for their colonoscopy During the procedure the research team member will record data onto the CRF procedural data findings at colonoscopy etc The colonoscopy report will be generated as per the usual practice in each unit
A subset of patients will undergo Fibroscan which is a non-invasive test to evaluate for liver fibrosis to explore the association between the presence of colorectal adenomaCRC and the presence of liver fibrosis
After the procedure the patient will enter the recovery ward and follow usual practice in the unit Although participants will remain in the study for 14 days to allow data collection and to follow-up any abnormal results participants will not require any further visits and the majority will not be contacted by the research team If a new abnormality is found on checking blood samples the patient will be contacted by a member of the research team and advised to make an appointment with their General Practitioner GP
Statistical analysis will be undertaken by Professor Steven Rushton Professor of Biological Modelling at Newcastle University
The primary outcome of this study is to develop a risk model which can be used to inform colorectal neoplasia screening and surveillance guidelines and to inform a future study targeting screening of higher risk individuals
The secondary outcomes will support this model by identifying which demographics contribute to increased predisposition to colorectal neoplasia namely smoking history alcohol intake and obesity measured by BMI and waist circumference The investigators also aim to assess whether the presence or degree of liver fibrosis as measured by FIB4 score and Fibroscan affects the risk of colorectal neoplasia and by exploring the link between NAFLD obesity and colorectal neoplasia in terms of adenoma burden site and histological features Lastly the association between abnormal liver enzymes and colorectal neoplasia will be explored
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None