Ignite Creation Date:
2024-05-06 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 12:52 PM
Study NCT ID:
NCT03641638
Status:
UNKNOWN
Last Update Posted:
2018-08-23
First Post:
2018-07-08
Brief Title:
Correlation Between Different Levels of Thyroid Peroxidase Antibody and Postpartum Thyroiditis in Early Pregnancy
Sponsor:
China National Nuclear Corporation 416 Hospital
Organization:
China National Nuclear Corporation 416 Hospital
Study Overview
Official Title:
Correlation Between Different Levels of Thyroid Peroxidase Antibody and Postpartum Thyroiditis in Early Pregancy
Status:
UNKNOWN
Status Verified Date:
2018-08
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
At present attention to thyroid disease during pregnancy is increasing at home and abroad but there is relatively little concern about postpartum thyroid disease especially high incidence of postpartum thyroiditis PPT This observational study is to investigate the relationship between different levels of thyroid peroxidase antibody TPOAb and postpartum thyroiditis PPT in early pregnancy 1-12 weeks of pregnancy and to explore whether PPT can be predicted by different TPOAb levels According to the TPOAb level in early pregnancy the postpartum of pregnant women was followed up PPT was detected early and intervention was performed according to thyroid dysfunction
Detailed Description:
First pregnant women who between the ages of 18 to 35 years old and normal thyroid function before pregnancy were selected Recruit 300 pregnant women who early pregnancy 1-12 weeks of pregnancy screening TPOAb positive and normal Free triiodothyronine FT3 normal free thyroxine FT4 Thyroid Stimulating Hormone TSH 478mIU L as the observation group They will be divided into low-level group TPOAb at 34-102 IUml medium-level group TPOAb at 103-204 IUml and high-level group TPOAb205 according to TPOAb Recruit 100 pregnant women who early pregnancy 1-12 weeks of pregnancy screening TPOAb negative and normal FT3 normal FT4TSH 478mIU L as the Control group
Thyroid function FT3 FT4 TSH and TPOAb thyroglobulin antibodyTgAb thyroid hormone receptor antibodyTRAb will be screened in the observation group and the control group at 3 months 6 months and 12 months after delivery If the mother is diagnosed with postpartum thyroiditis PPT continue to screen for thyroid function FT3 FT4 TSH and thyroid antibodies TPOAb TRAb TgAb 18 months after delivery The correlation between the early pregnancy TPOAb level and postpartum thyroiditis was analyzed between the observation group and the control group and the observation group It was explored whether the occurrence of postpartum thyroiditis PPT can be predicted according to the TPOAb level in the first trimester And targeted maternal effective follow-up and timely intervention to treat PPT provide important basis
Thyroid function FT3 FT4 TSH and TPOAb thyroglobulin antibodyTgAb thyroid hormone receptor antibodyTRAb will be screened in the observation group and the control group at 3 months 6 months and 12 months after delivery If the mother is diagnosed with postpartum thyroiditis PPT continue to screen for thyroid function FT3 FT4 TSH and thyroid antibodies TPOAb TRAb TgAb 18 months after delivery The correlation between the early pregnancy TPOAb level and postpartum thyroiditis was analyzed between the observation group and the control group and the observation group It was explored whether the occurrence of postpartum thyroiditis PPT can be predicted according to the TPOAb level in the first trimester And targeted maternal effective follow-up and timely intervention to treat PPT provide important basis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None