Ignite Creation Date:
2024-05-06 @ 11:58 AM
Last Modification Date:
2024-10-26 @ 12:52 PM
Study NCT ID:
NCT03642522
Status:
COMPLETED
Last Update Posted:
2021-01-12
First Post:
2018-08-09
Brief Title:
Investigating Predictors of Treatment Response in Treatment-Resistant Depression TRD With Interleaved TMSfMRI
Sponsor:
University of British Columbia
Organization:
University of British Columbia
Study Overview
Official Title:
Investigating Predictors of Treatment Response in Treatment-Resistant Depression TRD With Interleaved TMSfMRI
Status:
COMPLETED
Status Verified Date:
2021-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this trial is identify biomarkers of response to repetitive transcranial magnetic stimulation rTMS in individuals with first episode or treatment resistant depression These biomarkers include simultaneous TMS-fMRI functional magnetic resonance imaging a blood smear cognitive and behavioural assessments questionnaires and neurophysiology
Detailed Description:
This study is enrolling 60 individuals with treatment-resistant depression
All patients will receive four weeks of 1-Hz rTMS to the right dorsolateral prefrontal cortex R_DLPFC In addition all patients will undergo baseline and post-treatment measures including rTMS while they are in the MRI scanner neurophysiology Electroencephalography EEGNear-Infrared Spectroscopy NIRS cognitive testing behavioural assessments and a blood smear There will also be a 1-week 4-week and 12-week follow-up following completion of the treatment course
All patients will receive four weeks of 1-Hz rTMS to the right dorsolateral prefrontal cortex R_DLPFC In addition all patients will undergo baseline and post-treatment measures including rTMS while they are in the MRI scanner neurophysiology Electroencephalography EEGNear-Infrared Spectroscopy NIRS cognitive testing behavioural assessments and a blood smear There will also be a 1-week 4-week and 12-week follow-up following completion of the treatment course
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None