Ignite Creation Date:
2024-05-05 @ 4:47 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00312962
Status:
COMPLETED
Last Update Posted:
2014-03-11
First Post:
2006-04-07
Brief Title:
Effectiveness of Targeted Cognitive Training for Neurological Deficits in People With Schizophrenia
Sponsor:
University of California San Francisco
Organization:
University of California San Francisco
Study Overview
Official Title:
Neuroscience-Guided Remediation of Cognitive Deficits in Schizophrenia
Status:
COMPLETED
Status Verified Date:
2014-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CRIS
Brief Summary:
This study will determine the effectiveness of reward-intensive computer-based targeted cognitive training in improving neurocognitive deficits in people with schizophrenia
Detailed Description:
Schizophrenia is a chronic brain disorder that causes severe disability It is characterized by psychotic symptoms including hallucinations and delusions Neurocognitive deficits such as impaired neurocognitive processing efficiency also affect people with schizophrenia This deficiency in the speed and accuracy with which the brain perceives and responds to targets causes scrambled messages to be transmitted in the brain thereby affecting executive control and memory Medications are available that effectively treat the psychotic symptoms The neurocognitive deficits however do not subside with medication treatment and are responsible for the failure to improve the e their psychosocial functioning of people with schizophrenia even after their psychotic symptoms have gone into remission The targeted cognitive training TCT exercises in this study are specifically designed to improve speed and accuracy in the perception of and response to verbal and visuo-spatial targets This study will determine the effectiveness of reward-intensive computer-based TCT in improving neurocognitive deficits in people with schizophrenia
Participants in this double-blind study will be paired according to IQ and baseline symptom severity One member of each pair will be randomly assigned to training exercises that use TCT The other will be assigned to a control intervention which will involve commercially available computer games All participants will complete exercises with their assigned intervention for 1 hour per day 5 days per week until 90 hours of training has been accumulated Neuroimaging will be performed on a subgroup of participants to examine changes in brain activation patterns in response to the cognitive training Upon study completion and at the 6-month follow up visit participants will be assessed for improvement in the following areas cognitive performance symptom profile quality of life and social cue recognition
Participants in this double-blind study will be paired according to IQ and baseline symptom severity One member of each pair will be randomly assigned to training exercises that use TCT The other will be assigned to a control intervention which will involve commercially available computer games All participants will complete exercises with their assigned intervention for 1 hour per day 5 days per week until 90 hours of training has been accumulated Neuroimaging will be performed on a subgroup of participants to examine changes in brain activation patterns in response to the cognitive training Upon study completion and at the 6-month follow up visit participants will be assessed for improvement in the following areas cognitive performance symptom profile quality of life and social cue recognition
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DATR A2-AISZ | US NIH GrantContract | None | httpsreporternihgovquickSearchR01MH068725 |
| R01MH068725 | NIH | None | None |