Ignite Creation Date:
2024-05-06 @ 11:55 AM
Last Modification Date:
2024-10-26 @ 12:52 PM
Study NCT ID:
NCT03639909
Status:
COMPLETED
Last Update Posted:
2018-08-21
First Post:
2018-08-17
Brief Title:
Analysis of the Sweat Response According to the Pathology in Neurologic Patients
Sponsor:
University Hospital Toulouse
Organization:
University Hospital Toulouse
Study Overview
Official Title:
Analysis of the Sweat Response According to the Pathology in Neurologic
Status:
COMPLETED
Status Verified Date:
2018-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Sudoscan
Brief Summary:
Cardiovascular autonomic neuropathy CAN has been shown to be an important risk factor for cardiac diseases particularly in diabetes
CAN may be investigated by a battery of laboratory cardiovascular autonomic reflex testsinitially described by Ewing
First screening for CAN as proposed in diabetic patients can be performed by assessing heart rate HR response to deep breathing blood pressure BP and HR response to a 5 minutes stand test
CAN may be investigated by a battery of laboratory cardiovascular autonomic reflex testsinitially described by Ewing
First screening for CAN as proposed in diabetic patients can be performed by assessing heart rate HR response to deep breathing blood pressure BP and HR response to a 5 minutes stand test
Detailed Description:
Sweat glands are innervated by thin and un myelinated sympathetic C-fibers that can be impaired in neuropathiesespecially length-dependent ones Sweating dysfunction has been shown in several neurological peripheral disorders and it has been suggested that sweating function should be included among the diagnostic tests for the early detection of autonomic neuropathies Several methods have been developed but the lack of easy and quick tests to diagnose sweating dysfunction has restricted widespread use in clinical practice Measurement of electrochemical skin conductance ESC using Sudoscan is a new method for quick non-invasive and quantitative assessment of sweating This technique has demonstrated its usefulness in detecting autonomic and small fiber neuropathy especially in diabetic patientsThe aim of this study was to evaluate the performance of the laboratory battery of CV tests and of sweating dysfunction by Sudoscan alone or in combination to differentiate MSA-P from PD Among the CV tests the present study particularly looked at those tests already recommended as screening bedside tests in diabetic patients HR variations with deep breathing and BP variations during stand test these tests are rapid and easy to perform HR variations with deep breathing depend on parasympathetic tone and BP variations depend on vasomotor sympathetic response
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None