Ignite Creation Date:
2024-05-06 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 12:51 PM
Study NCT ID:
NCT03621384
Status:
COMPLETED
Last Update Posted:
2018-08-08
First Post:
2018-05-22
Brief Title:
Association of BsmI Polymorphisms in Vitamin D Receptor Gene With Diabetic Kidney Disease
Sponsor:
Indonesia University
Organization:
Indonesia University
Study Overview
Official Title:
Association of BsmI Polymorphisms in Vitamin D Receptor Gene With Diabetic Kidney Disease
Status:
COMPLETED
Status Verified Date:
2018-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background Diabetic kidney disease DKD as one of chronic complication of type 2 diabetes mellitus is common cause of end stage renal disease ESRD Vitamin D deficiency is known as one of DKD risk factors Recent studies on association between vitamin D deficiency and DKD had shown conflicting results It may be due to vitamin D receptor gene polymorphisms which is affected by BsmI Cdx2 ApaI FokI and TaqI gene The investigators conducted cross-sectional study to investigate association between BsmI polymorphisms in vitamin D receptor gene with diabetic kidney disease
Hypothesis BsmI polymorphisms in vitamin D receptor gene is associated with diabetic kidney disease DKD
Hypothesis BsmI polymorphisms in vitamin D receptor gene is associated with diabetic kidney disease DKD
Detailed Description:
Diabetic kidney disease DKD is a common cause of end stage renal disease ESRD Data from Indonesian Renal Registry 2011 revealed that 25 etiology of patients who underwent hemodialysis is DKD Risk factors that are associated with DKD include blood glucose control hypertension dyslipidemia duration of diabetes mellitus high body mass index BMI age sex ethnicity vitamin D deficiency high sodium diet high protein diet and smoking
The roles of vitamin D that are related to kidney are inhibition of renin transcription process angiotensin II renal inflammation process and albumin excretion prevention of podocytes damage glomerulosclerosis process and transformation from kidney epithelial cell into mesenchymal cell Current studies on association between vitamin D deficiency and DKD had shown conflicting results It may be related to genetic factor which is vitamin D receptor polymorphisms The vitamin D receptor polymorphism is affected by Cdx2 ApaI BsmI FokI and TaqI gene where Asian population is mostly affected by ApaI FokI and Cdx2
Several studies had reported the association between BsmI polymorphisms in vitamin D receptor gene and DKD in various population Zhang et al 2012 study revealed the association between BsmI polymorphisms in vitamin D receptor gene and DKD in Han Chinese population while study from Vedralova et al 2012 in Caucasian race showed opposite result However the association between BsmI polymorphism in vitamin D receptor gene and DKD has not been investigated in Indonesian-Malay race
This is a cross-sectional study that investigate the association between BsmI polymorphisms in vitamin D receptor gene and DKD in Indonesian-Malay race The investigators collected data about study participants characteristics conducted physical examination and laboratory examination which include BsmI polymorphisms in vitamin D receptor gene
The roles of vitamin D that are related to kidney are inhibition of renin transcription process angiotensin II renal inflammation process and albumin excretion prevention of podocytes damage glomerulosclerosis process and transformation from kidney epithelial cell into mesenchymal cell Current studies on association between vitamin D deficiency and DKD had shown conflicting results It may be related to genetic factor which is vitamin D receptor polymorphisms The vitamin D receptor polymorphism is affected by Cdx2 ApaI BsmI FokI and TaqI gene where Asian population is mostly affected by ApaI FokI and Cdx2
Several studies had reported the association between BsmI polymorphisms in vitamin D receptor gene and DKD in various population Zhang et al 2012 study revealed the association between BsmI polymorphisms in vitamin D receptor gene and DKD in Han Chinese population while study from Vedralova et al 2012 in Caucasian race showed opposite result However the association between BsmI polymorphism in vitamin D receptor gene and DKD has not been investigated in Indonesian-Malay race
This is a cross-sectional study that investigate the association between BsmI polymorphisms in vitamin D receptor gene and DKD in Indonesian-Malay race The investigators collected data about study participants characteristics conducted physical examination and laboratory examination which include BsmI polymorphisms in vitamin D receptor gene
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None