Ignite Creation Date:
2024-05-06 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 12:50 PM
Study NCT ID:
NCT03610386
Status:
COMPLETED
Last Update Posted:
2021-12-28
First Post:
2018-06-12
Brief Title:
Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus
Sponsor:
University Hospital Brest
Organization:
University Hospital Brest
Study Overview
Official Title:
In Vitro Study Of the Effects of the Menthoxypropanediol an Anti-TRPM8 in the Atopic Dermatitis Pruritus
Status:
COMPLETED
Status Verified Date:
2021-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DA-TRPM8
Brief Summary:
The aim of the study is to analyse the effect of the menthoxypropanediol a derivative of menthol on the pruritus of atopic dermatitis ex vivo study
Detailed Description:
AD is a fairly common pathology whose prevalence in Western Europe and the United States is estimated at 10 to 15 in children and 4 to 7 in adults This frequency has been steadily increasing for several decades However while the prevalence is increasing rapidly in emerging countries a plateau has been observed for a few years in the industrialized countries with a maximum of 20 reached in Northern Europe
The predominant symptom of AD is pruritus It has a strong impact on the lives of patients both physically psychologically and socially which causes stress and sleep disorders Because of this pruritus sleep disturbances but also the displaying character of the disease the quality of life of patients and their families is very often altered
The pathophysiology of this chronic pathology and associated pruritus is complex and incompletely understood and current treatments are unfortunately only symptomatic
Many receptors TRPA1 TRPV1 PAR2 molecules neuromediators neuropeptides histamine and secreted cytokines IL-2 -4 -13 and -31 TSLP are involved in the induction and mediation of chronic pruritus Their role in pruritus associated with AD begins to be understood Among them the TRPM 8 has a particular interest Indeed this receptor belongs to the superfamily of the potential transient receptor TRP whose members are known to play a major role in sensory perceptions including the perception of pruritus TRPM8 is a thermoreceptor activated by cold T 28 C or compounds such as menthol or derivatives or eucalyptus and the beneficial action of menthol in the soothing of pruritus makes the TRPM8 receptor an attractive therapeutic target for treatment of pruritus in AD Its role has never been studied in this context
This project aims to study the role of TRPM8 in the pathophysiology of pruritus in AD in an in vitro model Biopsies of atopic dermatitis patients 2patient in pruritic skin lesion will be put in culture and submit to topical application of menthoxypropanediol The effect of this molecule on receptors involved in pruritus pathway will be assay immunohistochemistry QPCR
The predominant symptom of AD is pruritus It has a strong impact on the lives of patients both physically psychologically and socially which causes stress and sleep disorders Because of this pruritus sleep disturbances but also the displaying character of the disease the quality of life of patients and their families is very often altered
The pathophysiology of this chronic pathology and associated pruritus is complex and incompletely understood and current treatments are unfortunately only symptomatic
Many receptors TRPA1 TRPV1 PAR2 molecules neuromediators neuropeptides histamine and secreted cytokines IL-2 -4 -13 and -31 TSLP are involved in the induction and mediation of chronic pruritus Their role in pruritus associated with AD begins to be understood Among them the TRPM 8 has a particular interest Indeed this receptor belongs to the superfamily of the potential transient receptor TRP whose members are known to play a major role in sensory perceptions including the perception of pruritus TRPM8 is a thermoreceptor activated by cold T 28 C or compounds such as menthol or derivatives or eucalyptus and the beneficial action of menthol in the soothing of pruritus makes the TRPM8 receptor an attractive therapeutic target for treatment of pruritus in AD Its role has never been studied in this context
This project aims to study the role of TRPM8 in the pathophysiology of pruritus in AD in an in vitro model Biopsies of atopic dermatitis patients 2patient in pruritic skin lesion will be put in culture and submit to topical application of menthoxypropanediol The effect of this molecule on receptors involved in pruritus pathway will be assay immunohistochemistry QPCR
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None