Ignite Creation Date:
2024-05-06 @ 11:49 AM
Last Modification Date:
2024-10-26 @ 12:50 PM
Study NCT ID:
NCT03606473
Status:
COMPLETED
Last Update Posted:
2020-09-03
First Post:
2018-07-20
Brief Title:
Brain Mechanisms in Young Adults
Sponsor:
Gale Richardson
Organization:
University of Pittsburgh
Study Overview
Official Title:
Exploration of Mechanisms of Effects of Prenatal Cocaine Exposure in Young Adults
Status:
COMPLETED
Status Verified Date:
2020-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MHP
Brief Summary:
The goal of this study is to use C-11NPA and amphetamine oral 05 mgkg to measure striatal dopamine transmission in prenatal cocaine exposed subjects PCE and comparison subjects COMP
Detailed Description:
Prenatal cocaine exposure PCE has consistently been associated with behavioral deficits through childhood adolescence and young adulthood in our ongoing study PRO15080516 - Effects of Prenatal Cocaine Use 25-Year Follow-Up Further 21-year-olds with PCE in our study were twice as likely to have been arrested as non-exposed offspring were more likely to be diagnosed with Conduct Disorder had higher disinhibition scores were significantly more likely to use alcohol and marijuana earlier and to have earlier sexual intercourse The effects of PCE on the developing nervous system may cause changes in brain function that underlie these behavioral outcomes
This study seeks to examine dopamine DA transmission in vivo using positron emission tomography PET with C-11NPA in striatal regions of interest in subjects who have a history of exposure to prenatal cocaine PCE We hypothesize that PCE is associated with increases in dopamine in the striatum relative to COMP This may explain the impulsivity and high risk behaviors in PCE subjects
This study seeks to examine dopamine DA transmission in vivo using positron emission tomography PET with C-11NPA in striatal regions of interest in subjects who have a history of exposure to prenatal cocaine PCE We hypothesize that PCE is associated with increases in dopamine in the striatum relative to COMP This may explain the impulsivity and high risk behaviors in PCE subjects
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?:
None