Ignite Creation Date:
2024-05-06 @ 11:48 AM
Last Modification Date:
2024-10-26 @ 12:50 PM
Study NCT ID:
NCT03602521
Status:
COMPLETED
Last Update Posted:
2023-12-20
First Post:
2018-07-18
Brief Title:
Reactivity of Patients With Borderline Personality Disorder to an Ecological Interpersonal Stress
Sponsor:
University Hospital Montpellier
Organization:
University Hospital Montpellier
Study Overview
Official Title:
Reactivity of Patients With Borderline Personality Disorder to an Ecological Interpersonal Stress Pathophysiology of Suicidal Behaviors Study Model
Status:
COMPLETED
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ROI
Brief Summary:
Use lay language
According to the World Health Organization 1 death by suicide occurs every 40 seconds leading suicide prevention to one of the public health priority
BPD Borderline Personality Disorder is a common condition affecting 6 of the population
This disorder is characterized by unstable emotions unstable mood difficulties with relationship and feer of abandonment
Borderline Personality Disorder is also the psychopathology the most related to suicidal attempts
Indeed up to 50 of the patients admitted to hospital after a suicide attempt are diagnosis with a Borderline Personality Disorder
Negative interpersonal events events occurring between two people are known as the main stressor that trigger a suicidal attempt
People with a Borderline Personality Disorder are highly sensitive to it
Moreover neuropeptides such as oxytocin OXT vasopressin and opioid are known to be involved in the regulation of the emotions especially those linked to relationship
The purpose of this study is to improve knowledge in suicidal behaviors
After simulating an interpersonal stress the evolution of plasma neuropeptides level OXT vasopressin and opioid of patients with a BPD will be compared to healthy controls HC
Clinical data reflecting how the participant is feeling will be collected as well
According to the World Health Organization 1 death by suicide occurs every 40 seconds leading suicide prevention to one of the public health priority
BPD Borderline Personality Disorder is a common condition affecting 6 of the population
This disorder is characterized by unstable emotions unstable mood difficulties with relationship and feer of abandonment
Borderline Personality Disorder is also the psychopathology the most related to suicidal attempts
Indeed up to 50 of the patients admitted to hospital after a suicide attempt are diagnosis with a Borderline Personality Disorder
Negative interpersonal events events occurring between two people are known as the main stressor that trigger a suicidal attempt
People with a Borderline Personality Disorder are highly sensitive to it
Moreover neuropeptides such as oxytocin OXT vasopressin and opioid are known to be involved in the regulation of the emotions especially those linked to relationship
The purpose of this study is to improve knowledge in suicidal behaviors
After simulating an interpersonal stress the evolution of plasma neuropeptides level OXT vasopressin and opioid of patients with a BPD will be compared to healthy controls HC
Clinical data reflecting how the participant is feeling will be collected as well
Detailed Description:
A dysregulation of the neuropeptides OXT vasopressin and opioid could explain the dysregulation of the emotions of people with Borderline Personality Disorder
Up to this date there is no other study measuring neuropeptides kinetics of patient with Borderline Personality Disorder after an interpersonal stress
This task of stress is meant to reproduce what people with Borderline Personality Disorder suffer in their everyday life ecological
To reach this point an imaginary interpersonal stress will be asked to be reproduced by the participants
Neuropeptides concentrations and clinical data fear shame anger moral pain compelling needs suicidal and non-suicidal will be collected at different times pre stress post stress immediat 5 minutes post stress15 minutes post stress and 40 minutes post stress
As copeptin fragment C terminal of the vasopressin and vasopressin are found in stoichiometric concentration in the plasma as copeptin is more stable than vasopressin plasma copeptin level will be used to reflect the one of vasopressin
The hypothesis is that both the neuropeptide variation and clinical data before and after the interpersonal stress will be higher for the patient with Borderline Personality Disorder than healthy controls
A correlation between clinical assessments and neuropeptides kinetics is expected This study will help to identify inter-individual and contextual factors impacting neuropeptides kinetics
Up to this date there is no other study measuring neuropeptides kinetics of patient with Borderline Personality Disorder after an interpersonal stress
This task of stress is meant to reproduce what people with Borderline Personality Disorder suffer in their everyday life ecological
To reach this point an imaginary interpersonal stress will be asked to be reproduced by the participants
Neuropeptides concentrations and clinical data fear shame anger moral pain compelling needs suicidal and non-suicidal will be collected at different times pre stress post stress immediat 5 minutes post stress15 minutes post stress and 40 minutes post stress
As copeptin fragment C terminal of the vasopressin and vasopressin are found in stoichiometric concentration in the plasma as copeptin is more stable than vasopressin plasma copeptin level will be used to reflect the one of vasopressin
The hypothesis is that both the neuropeptide variation and clinical data before and after the interpersonal stress will be higher for the patient with Borderline Personality Disorder than healthy controls
A correlation between clinical assessments and neuropeptides kinetics is expected This study will help to identify inter-individual and contextual factors impacting neuropeptides kinetics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None