Ignite Creation Date:
2024-05-06 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 12:50 PM
Study NCT ID:
NCT03603561
Status:
UNKNOWN
Last Update Posted:
2019-04-25
First Post:
2018-06-05
Brief Title:
Continuous Theta Burst Stimulation as an add-on Treatment for Bipolar Depression
Sponsor:
Universiteit Antwerpen
Organization:
Universiteit Antwerpen
Study Overview
Official Title:
Continuous Theta Burst Transcranial Magnetic Stimulation as an add-on Treatment for Bipolar Depression a Multicenter Randomized Sham-controlled Trial
Status:
UNKNOWN
Status Verified Date:
2019-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to investigate the clinical efficacy of continuous theta burst stimulation cTBS on the right DLPFC as an add-on treatment in bipolar depression The study consists of three phases
Phase 1 Bipolar depressed patients will be selected by a certified psychiatrist who will administer semi-structured clinical interviews MINI-Plus 500 HRSD-17 The presence of exclusion criteria will be evaluated Eligible patients will undergo MRI brain imaging for TMS neuronavigation
Phase 2 Baseline clinical cognitive and psychomotor assessments will take place Patients will also undergo blood samples for laboratory and research assessments
TBS involves applying triple-pulse 50 Hz bursts given at a rate of 5 Hz uninterrupted trains 1 Patients will be treated with in total 20 continuous Theta Burst Stimulation cTBS session 900 pulses per session over the right dorsolateral prefrontal cortex which will be spread over 4 days A stimulation intensity of 100 of the subjects resting motor threshold rMT of the right abductor pollicis brevis muscle will used
Patients will be randomized to receive either the real cTBS or sham treatment Sham stimulation will be applied with a sham coil The sham coil produces identical sounds but is not associated with a stimulus sensation compared to the coil delivering real stimulation cTBS The investigators expect that real cTBS treatment and not sham will result in a significant and clinical meaningful response
Phase 3 Two post-treatment assessment moments will take place respectively 3 max 4 days and 10 max 11 days after the last treatment day The assessments are the same clinical cognitive and psychomotor assessments as in phase 2
Phase 1 Bipolar depressed patients will be selected by a certified psychiatrist who will administer semi-structured clinical interviews MINI-Plus 500 HRSD-17 The presence of exclusion criteria will be evaluated Eligible patients will undergo MRI brain imaging for TMS neuronavigation
Phase 2 Baseline clinical cognitive and psychomotor assessments will take place Patients will also undergo blood samples for laboratory and research assessments
TBS involves applying triple-pulse 50 Hz bursts given at a rate of 5 Hz uninterrupted trains 1 Patients will be treated with in total 20 continuous Theta Burst Stimulation cTBS session 900 pulses per session over the right dorsolateral prefrontal cortex which will be spread over 4 days A stimulation intensity of 100 of the subjects resting motor threshold rMT of the right abductor pollicis brevis muscle will used
Patients will be randomized to receive either the real cTBS or sham treatment Sham stimulation will be applied with a sham coil The sham coil produces identical sounds but is not associated with a stimulus sensation compared to the coil delivering real stimulation cTBS The investigators expect that real cTBS treatment and not sham will result in a significant and clinical meaningful response
Phase 3 Two post-treatment assessment moments will take place respectively 3 max 4 days and 10 max 11 days after the last treatment day The assessments are the same clinical cognitive and psychomotor assessments as in phase 2
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None