Ignite Creation Date:
2024-05-06 @ 11:47 AM
Last Modification Date:
2024-10-26 @ 12:50 PM
Study NCT ID:
NCT03608215
Status:
COMPLETED
Last Update Posted:
2019-02-15
First Post:
2018-07-24
Brief Title:
Neuromodulatary Efficacy of Transcranial Direct Current Stimulation in Severe Refractory Primary Dysmenorrhea
Sponsor:
Taipei Veterans General Hospital Taiwan
Organization:
Taipei Veterans General Hospital Taiwan
Study Overview
Official Title:
Neuromodulation Effect of Transcranial Direct Current Stimulation in Severe Refractory Primary Dysmenorrhea BDNF and MEG Study
Status:
COMPLETED
Status Verified Date:
2019-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Primary Dysmenorrhea PDM defined as menstrual pain without discernable organic causes is inexorably common in adolescent women about 40-90 of women may suffer from it and 20 of them can be severe in the context of being refractory to medication daily function impairment and having pain of severe degree Novel therapeutic method is in need for pain alleviation for this particular phenotype It has been reported that PDM females may engage motor-cortex based descending pain modulation system in our resting-state functional Magnetic Resonance Imaging rs-fMRI and thermal pain-activation fMRI studies Based on the reported analgesic efficacy of transcranial Direct Current Stimulation tDCS on the motor cortex for various experimental painful conditions and clinical pain disorders it is plausible that tDCS can be effective for the severe and medication-refractory PDM patients This study aim to investigate the analgesic efficacy of tDCS in severe PDMs and to elucidate the dynamic brain neuroplasticity in the context of experimental pain after tDCS intervention Thirty severe PDMs will be recruited and randomly allocated to either real or sham group in a triple-blind manner Experimental pain electrical stimulation will be performed before and after the tDCS intervention The experimental pain-evoked magnetoencephamographic MEG data will be correlated with behavioral and psychological measurements This is the first study in the literature investigating the tDCS efficacy for acute pain in severe PDM The result can promise a new possibility for clinical application
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None