Ignite Creation Date:
2024-05-05 @ 4:46 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00315575
Status:
COMPLETED
Last Update Posted:
2009-01-26
First Post:
2006-04-14
Brief Title:
Memory Imaging of Normal Aging
Sponsor:
National Institute on Aging NIA
Organization:
National Institute on Aging NIA
Study Overview
Official Title:
BOLD and Perfusion fMRI of Alzheimers Disease Risk
Status:
COMPLETED
Status Verified Date:
2009-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to develop imaging techniques that can distinguish functional brain changes in people at high risk for dementia years prior to onset of clinical memory problems from those with normal changes of aging
Detailed Description:
The overall goals of this project are to identify consistent patterns of variance in brain function in patients at risk for Alzheimers Disease by using APOE ε4 as a marker for disease risk The activation Blood Oxygen Level Dependency BOLD signal will be compared to both resting and activation perfusion signals to assess the variability of cerebral blood flow as it relates to the BOLD signal Each participant will be imaged on a 3T MRI scanner while performing an associate episodic memory task
A total of 90 individuals will be recruited for this study Participants will be non-demented right handed adults with or without at least one APOE ε4 allele Groups will be split as follows A ages 25-39 non-ε4 n15 B ages 25-39 ε4 n15 C ages 40-49 non-ε4 n15 D ages 40-49 ε4 n15E ages 50-65 non-ε4 F ages 50-65 ε4 n15 These groups will be matched for mean age mean years of education gender distribution as well as the presence or absence of a family history of AD in a first degree relative
There will be 2 scanning sessions for each participant Scan session 1 and Scan session 2 will be acquired within 2 weeks of each other and will take approximately one hour each
A total of 90 individuals will be recruited for this study Participants will be non-demented right handed adults with or without at least one APOE ε4 allele Groups will be split as follows A ages 25-39 non-ε4 n15 B ages 25-39 ε4 n15 C ages 40-49 non-ε4 n15 D ages 40-49 ε4 n15E ages 50-65 non-ε4 F ages 50-65 ε4 n15 These groups will be matched for mean age mean years of education gender distribution as well as the presence or absence of a family history of AD in a first degree relative
There will be 2 scanning sessions for each participant Scan session 1 and Scan session 2 will be acquired within 2 weeks of each other and will take approximately one hour each
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5K23AG024062-02 | NIH | None | httpsreporternihgovquickSearch5K23AG024062-02 |