Ignite Creation Date:
2024-05-06 @ 11:46 AM
Last Modification Date:
2024-10-26 @ 12:49 PM
Study NCT ID:
NCT03591939
Status:
UNKNOWN
Last Update Posted:
2018-07-19
First Post:
2018-07-08
Brief Title:
T-regulatory Cells in Diabetic Type Two Nephropathy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Role of T-regulatory Cells in Type Two Diabetic Nephropathy
Status:
UNKNOWN
Status Verified Date:
2018-07
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Diabetes mellitus is one of the most prevalent health problems worldwide Diabetic nephropathy has become the leading cause of end-stage kidney disease worldwide and is associated with an increased cardiovascular risk
Traditionally metabolic and hemodynamic factors are the main causes of renal lesions in patients with type two diabetes mellitus and diabetic nephropathy both considered non-immune diseases Serial researches has demonstrated that diabetic nephropathy is a metabolic and hemodynamic disorder with inflammation playing a vital role in the process
Traditionally metabolic and hemodynamic factors are the main causes of renal lesions in patients with type two diabetes mellitus and diabetic nephropathy both considered non-immune diseases Serial researches has demonstrated that diabetic nephropathy is a metabolic and hemodynamic disorder with inflammation playing a vital role in the process
Detailed Description:
It has been reported that glomerular basement membranes from diabetic rats induced significantly greater amounts of Tumor necrotic factor-alpha and Interleukin-1 than when these cells were incubated with basement membranes from non-diabetic rats
These new findings were the first to suggest that inflammatory cytokines may participate in the pathogenesis of diabetic nephropathy Cluster of differentiation 4 cells are believed to play central roles in modulating immune responses Tumor necrotic factor-alpha and Interleukin-6 and induce inflammation in the pathogenesis of autoimmune diseases
T- regulatory cells exert immunosuppressive effects which are important on the maintenance of immune homeostasis by producing anti-inflammatory cytokines such as Interleukin-10 and transforming growth factor-b
Aim of this work is to the role of T regulatory cells Cluster of differentiation 4 Cluster of differentiation 25Cluster of differentiation 127 forkhead box P3 cells in the different stages of diabetic nephropathy before hemodialysis initiation
These new findings were the first to suggest that inflammatory cytokines may participate in the pathogenesis of diabetic nephropathy Cluster of differentiation 4 cells are believed to play central roles in modulating immune responses Tumor necrotic factor-alpha and Interleukin-6 and induce inflammation in the pathogenesis of autoimmune diseases
T- regulatory cells exert immunosuppressive effects which are important on the maintenance of immune homeostasis by producing anti-inflammatory cytokines such as Interleukin-10 and transforming growth factor-b
Aim of this work is to the role of T regulatory cells Cluster of differentiation 4 Cluster of differentiation 25Cluster of differentiation 127 forkhead box P3 cells in the different stages of diabetic nephropathy before hemodialysis initiation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None