Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005434
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Opioid Compromise in Hypertension--Modulating Factors
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To confirm the preliminary findings of age race and hypertension chronicity effects on opioid and cardiovascular responses to stress and to determine the opioid mechanisms mediating these effects using an opioid receptor blockade strategy
Detailed Description:
BACKGROUND
Opioids exert depressor effects on cardiovascular responses through sympathetic nervous system inhibition Research suggests that opioid inhibition of sympathetic activity may be compromised in hypertension Preliminary studies by the Principal Investigator suggest that the nature of this compromise may be influenced by age and race Additionally literature suggests that hypertension chronicity may modulate opioid sympathoinhibitory actions The receptor mechanisms mediating the observed modulating effects of age race and hypertension chronicity on opioidergic inhibition and regulation of blood pressure remained to be determined
DESIGN NARRATIVE
Two double-blind placebo-controlled cross-over studies were conducted to evaluate the effects of naltrexone hydrochloride an oral opiate antagonist on adrenergically-mediated cardiovascular responses in older and younger Black and White normotensives and hypertensives with varying lengths of hypertension duration Cardiovascular and opioid responses were measured in response to a stressor combined with either placebo or naltrexone pretreatment Results from these studies assisted in a elucidating opioidergic mechanisms underlying the increased rates of hypertension morbidity and mortality among Blacks and the elderly and b ultimately optimized the design of pharmacological interventions for the prevention and treatment of hypertension
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Opioids exert depressor effects on cardiovascular responses through sympathetic nervous system inhibition Research suggests that opioid inhibition of sympathetic activity may be compromised in hypertension Preliminary studies by the Principal Investigator suggest that the nature of this compromise may be influenced by age and race Additionally literature suggests that hypertension chronicity may modulate opioid sympathoinhibitory actions The receptor mechanisms mediating the observed modulating effects of age race and hypertension chronicity on opioidergic inhibition and regulation of blood pressure remained to be determined
DESIGN NARRATIVE
Two double-blind placebo-controlled cross-over studies were conducted to evaluate the effects of naltrexone hydrochloride an oral opiate antagonist on adrenergically-mediated cardiovascular responses in older and younger Black and White normotensives and hypertensives with varying lengths of hypertension duration Cardiovascular and opioid responses were measured in response to a stressor combined with either placebo or naltrexone pretreatment Results from these studies assisted in a elucidating opioidergic mechanisms underlying the increased rates of hypertension morbidity and mortality among Blacks and the elderly and b ultimately optimized the design of pharmacological interventions for the prevention and treatment of hypertension
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R29HL046218 | NIH | None | httpsreporternihgovquickSearchR29HL046218 |