Ignite Creation Date:
2024-05-05 @ 4:46 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00312403
Status:
COMPLETED
Last Update Posted:
2010-01-15
First Post:
2006-04-06
Brief Title:
Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1 MMP3 and MMP9 Genetic Risk Factors of Primary Open Angle Glaucoma
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1 MMP3 and MMP9 Genetic Risk Factors of Primary Open Angle Glaucoma
Status:
COMPLETED
Status Verified Date:
2010-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Matrix metalloproteinases MMPs fulfill diverse important molecular functions and play pivotal roles in development tissue morphogenesis repair aging and inflammatory processes MMPs are also important disease modulating factors such as cancer cardiovascular disease rheumatoid arthritis or macular degeneration Functional genetic variants have been described to fine-tune MMP activities at the gene transcriptional level and have been associated with increased genetic risk of eg arteriosclerosis or cancer MMPs are also assumed to play a major role in the remodeling of the extracellular matrix ECM in the optic nerve head during glaucomatous optic neuropathy MMP-1 MMP-3 and MMP-9 have been shown to be up-regulated in a variety of animal models of glaucoma Here we study three promoter SNPs within the genes encoding three members of the MMP family By assessing the prevalence of genetic variants associated with either increaseddecreased enzyme activity we will i estimate their contribution to the genetic risk of developing primary open angle glaucoma POAG and ii investigate the potential role of MMPs in the functional pathology of POAG
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None