Ignite Creation Date:
2024-05-06 @ 11:42 AM
Last Modification Date:
2024-10-26 @ 12:49 PM
Study NCT ID:
NCT03587324
Status:
COMPLETED
Last Update Posted:
2018-07-18
First Post:
2018-07-02
Brief Title:
Perioperative Aspirin Response in Patients Undergoing Vascular Surgery
Sponsor:
St Josef Hospital Bochum
Organization:
St Josef Hospital Bochum
Study Overview
Official Title:
Perioperative Risk Factors for the Development of Aspirin Low Response in Patients Undergoing Vascular Surgery
Status:
COMPLETED
Status Verified Date:
2018-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Reduced antiplatelet activity low response LRhigh on-treatment platelet reactivity HPR of aspirin ALR or clopidogrel CLR is associated with an increased risk of thromboembolic events The prevalence figures for low-responders reported in the literature vary widely and there have been few investigations in vascular surgery patients to date The aim of this prospective monocentric study was to increase the evidence base on vascular surgery patients and to detect any changes in the response following vascular surgery procedures
Detailed Description:
The activity of aspirin acetylsalicylic acid ASA and clopidogrel is measured by whole blood impedance aggregometry using a multiple electrode aggregometer Multiplate The agonists used are arachidonic acid for aspirin and adenosine diphosphate ADP for clopidogrel Vascular patients requiring treatment for peripheral artery disease PAD andor carotid stenosis are included in the study To identify possible risk factors demographic data concomitant medication laboratory parameters co-morbidities severity of the condition and the type of procedure performed are documented In addition a follow-up aggregometry is performed after completion of the vascular procedure
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None