Ignite Creation Date:
2024-05-06 @ 11:42 AM
Last Modification Date:
2024-10-26 @ 12:49 PM
Study NCT ID:
NCT03587220
Status:
COMPLETED
Last Update Posted:
2020-04-20
First Post:
2018-06-21
Brief Title:
A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin
Sponsor:
Aalborg University
Organization:
Aalborg University
Study Overview
Official Title:
En undersøgelse af Mekanismerne Bag Nociceptiv Desensibilisering forårsaget af Topikal Capsaicin
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this project is to study the role of transient receptor potential TRP- channel V1 TRPV1 fibers in the development of cutaneous inflammation induced by epidermal Ultraviolet-B damage Moreover in this project the investigators want to evaluate if the capsaicin-desensitization action can still be induced in a skin area pretreated with topical local anesthetic lidocaine
Detailed Description:
In this project the Ultraviolet- B pain model a model using type B ultraviolet rays to induce a first-degree sunburn will be used to induce a non-specific inflammation in the skin This model is well-known to produce both peripheral and central hyperalgesia through sensitization of peripheral and central nociceptors Capsaicin the active substance in chili peppers is currently used to treat peripheral neuropathic pain and prolonged application of 8 capsaicin patch causes profound desensitization to painful heat stimuli and itch provocations Therefore the investigators would like to monitor the development of unspecific UVB-cutaneous inflammation and consequent neurogenic flare in a capsaicin pre-treated area Moreover the investigators want to test if pre-treating the skin with lidocaine can reduce the pain associated with the capsaicin application without affecting its desensitization action
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None