Ignite Creation Date:
2024-05-06 @ 11:42 AM
Last Modification Date:
2024-10-26 @ 12:48 PM
Study NCT ID:
NCT03572556
Status:
COMPLETED
Last Update Posted:
2020-11-20
First Post:
2018-06-08
Brief Title:
Prospective Descriptive Study of the Angiogenic T Cell Population in Subjects With Hereditary Hemorrhagic Telangiectasia HHT
Sponsor:
Centre Hospitalier Universitaire Dijon
Organization:
Centre Hospitalier Universitaire Dijon
Study Overview
Official Title:
Prospective Descriptive Study of the Angiogenic T Cell Population in Subjects With Hereditary Hemorrhagic Telangiectasia HHT
Status:
COMPLETED
Status Verified Date:
2019-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TangRO
Brief Summary:
Hereditary hemorrhagic telangiectasia HHT results from genetic deregulation of angiogenesis It is characterized by mucocutaneous telangiectasia responsible for recurrent epistaxis affecting quality of life anaemia iron deficiency social distress More rarely HHT is complicated by the appearance of pulmonary hepatic or cerebral arteriovenous malformations that can lead to serious complications cerebrovascular accidents cerebral abscesses high output heart failure and massive hemoptysis 1 The intensity of symptoms increases with age but with significant individual variability even for the same mutation in the same family Thus while the mutations responsible for the disease have been identified the pathophysiology is not fully understood because these mutations do not explain the great diversity of clinical presentations Other factors not yet identified probably play an important role Angiogenic T cells TANG are a newly individualized T cell population defined by a CD4CXCR4CD31 phenotype which plays a key role in differentiating endothelial progenitors 2
In an earlier study the investigators showed that patients with HHT had a decrease in CD4 and CD8 LT compared to a cohort of healthy subjects 3
They hypothesize that the lymphopenia mainly involves TANG whose quantification could make it possible to assess the individual level of angiogenesis during HHT The evaluation of the TANG levels could thus make it possible to personalize HHT management
In an earlier study the investigators showed that patients with HHT had a decrease in CD4 and CD8 LT compared to a cohort of healthy subjects 3
They hypothesize that the lymphopenia mainly involves TANG whose quantification could make it possible to assess the individual level of angiogenesis during HHT The evaluation of the TANG levels could thus make it possible to personalize HHT management
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None