Ignite Creation Date:
2024-05-06 @ 11:40 AM
Last Modification Date:
2024-10-26 @ 12:48 PM
Study NCT ID:
NCT03577639
Status:
COMPLETED
Last Update Posted:
2021-04-29
First Post:
2018-06-13
Brief Title:
Diet Quality and Genetic Association With Body Mass Index Results From Three Observational Studies
Sponsor:
Harvard School of Public Health HSPH
Organization:
Harvard School of Public Health HSPH
Study Overview
Official Title:
Diet Quality and Genetic Association With Body Mass Index Results From Three Observational Studies
Status:
COMPLETED
Status Verified Date:
2021-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background In the most recent genome-wide association study GWAS of the 97 body mass index BMI-associated single nucleotide polymorphisms SNPs identified more than half of the SNPs were highly enriched for expression in the central nervous system CNS which is the key site of central appetite regulation 1 Significant interaction between consumption of sugar-sweetened beverages and genetic score in relation to BMI has been found 2 However it is not known whether diet quality could modify the genetic association with BMI Moreover identification of subgroup of established SNPs whose association with BMI could be most significantly modified by diet will provide evidence to individualized obesity prevention
Hypotheses
SNPs enriched in the CNS CNS SNPs were more likely to be associated with food and nutrient intakes featured in alternative healthy eating index AHEI in comparison to SNPs enriched in other tissues non-CNS SNPs
Higher diet quality was related with less pronounced association between genetic score and BMI particularly the score of CNS SNPs
Study Population
5730 women in the Nurses Health Study NHS and 3434 men in the Health Professional Follow-up Study HPFS who were sampled as controls
21740 women in the Womens Genome Health Study WGHS Exposure
Dietary quality will be measured by AHEI-2010 alternate Mediterranean diet AMED and the Dietary Approaches to Stop Hypertension DASH diet scores Diet was measured repeatedly in the NHS 1984 1986 1990 1994 and the HPFS 1986 1990 1994 and was measured at baseline in the WGHS
Based on the most recent GWAS 1 we will classify the 97 BMI-associated SNPs into CNS SNP 54 SNPs and non-CNS SNP 43 SNPs Total CNS and non-CNS SNP scores will be calculated
Outcome BMI measured after diet assessment with 2-year lag in the NHS and the HPFS and 3-year lag in the WGHS Statistical analysis
1 The associations of individual SNP with AHEI components at baseline will be examined using linear regression and the results will be presented in Heatmap
2 The interactions between diet quality scores and genetic scores in relation to BMI will be examined using generalized linear model in the NHS and the HPFS and using linear regression in the WGHS The genetic scores will include total SNP score CNS SNP score and non-CNS SNP score
3 Two-way stratification analysis will be conducted the association of diet quality score with BMI will be stratified by genetic score the association of genetic score with BMI will be stratified by diet quality score
4 The interactions between AHEI components and genetic scores in relation to BMI will be examined using generalized linear model in the NHS and the HPFS and using linear regression in the WGHS
Hypotheses
SNPs enriched in the CNS CNS SNPs were more likely to be associated with food and nutrient intakes featured in alternative healthy eating index AHEI in comparison to SNPs enriched in other tissues non-CNS SNPs
Higher diet quality was related with less pronounced association between genetic score and BMI particularly the score of CNS SNPs
Study Population
5730 women in the Nurses Health Study NHS and 3434 men in the Health Professional Follow-up Study HPFS who were sampled as controls
21740 women in the Womens Genome Health Study WGHS Exposure
Dietary quality will be measured by AHEI-2010 alternate Mediterranean diet AMED and the Dietary Approaches to Stop Hypertension DASH diet scores Diet was measured repeatedly in the NHS 1984 1986 1990 1994 and the HPFS 1986 1990 1994 and was measured at baseline in the WGHS
Based on the most recent GWAS 1 we will classify the 97 BMI-associated SNPs into CNS SNP 54 SNPs and non-CNS SNP 43 SNPs Total CNS and non-CNS SNP scores will be calculated
Outcome BMI measured after diet assessment with 2-year lag in the NHS and the HPFS and 3-year lag in the WGHS Statistical analysis
1 The associations of individual SNP with AHEI components at baseline will be examined using linear regression and the results will be presented in Heatmap
2 The interactions between diet quality scores and genetic scores in relation to BMI will be examined using generalized linear model in the NHS and the HPFS and using linear regression in the WGHS The genetic scores will include total SNP score CNS SNP score and non-CNS SNP score
3 Two-way stratification analysis will be conducted the association of diet quality score with BMI will be stratified by genetic score the association of genetic score with BMI will be stratified by diet quality score
4 The interactions between AHEI components and genetic scores in relation to BMI will be examined using generalized linear model in the NHS and the HPFS and using linear regression in the WGHS
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None