Ignite Creation Date:
2024-05-06 @ 11:40 AM
Last Modification Date:
2024-10-26 @ 12:48 PM
Study NCT ID:
NCT03570216
Status:
COMPLETED
Last Update Posted:
2021-02-26
First Post:
2018-03-26
Brief Title:
Cardiovascular Effects of Acute Exercise Post-Stroke
Sponsor:
McMaster University
Organization:
McMaster University
Study Overview
Official Title:
Acute Effects of High-Intensity Interval Exercise vs Moderate-Intensity Continuous Exercise on Arterial Stiffness in Chronic Stroke
Status:
COMPLETED
Status Verified Date:
2021-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ACES
Brief Summary:
There is an urgent need to reduce the impact of stroke by promoting optimal rehabilitation strategies that decrease the risk of stroke Improving cardiovascular health following a stroke is a key rehabilitation strategy that has the potential to reduce the risk of a recurrent event
Adverse cardiovascular events including stroke are often due to chronic atherosclerosis which shows as increased arterial stiffness Elevated arterial stiffness is prevalent in individuals with cardiovascular disease is associated with markers of silent cerebrovascular disease and is a new marker for predicting cardiovascular risk Cardiopulmonary exercise tests CPETs are used to assess cardiorespiratory fitness Novel CPET protocols have emerged for stroke enabling safe and valid measurements of cardiorespiratory fitness Cardiovascular exercise typically performed through moderate-intensity continuous exercise MICE can improve function and fitness in individuals living with stroke and lower the risk of recurrent stroke Recently high-intensity interval exercise HIIE has emerged as a potentially potent stimulus that may also lead to improvements in function and fitness While HIIE has shown benefits in clinical and non-clinical populations only a few small preliminary studies have examined the effects of HIIE in individuals living with stroke and most have primarily focused on examining the effects of HIIE on function and gait No study has examined and compared the acute effects of a CPET MICE and HIIE on arterial stiffness in stroke This study will 1 examine the acute effects of a single session of this HIIE protocol compared to a CPET and a single session of MICE on arterial stiffness among individuals with chronic stroke and 2 the feasibility of a high-intensity interval training exercise protocol previously found to be tolerable and effective in attaining high levels of exercise intensity in in these individuals
Adverse cardiovascular events including stroke are often due to chronic atherosclerosis which shows as increased arterial stiffness Elevated arterial stiffness is prevalent in individuals with cardiovascular disease is associated with markers of silent cerebrovascular disease and is a new marker for predicting cardiovascular risk Cardiopulmonary exercise tests CPETs are used to assess cardiorespiratory fitness Novel CPET protocols have emerged for stroke enabling safe and valid measurements of cardiorespiratory fitness Cardiovascular exercise typically performed through moderate-intensity continuous exercise MICE can improve function and fitness in individuals living with stroke and lower the risk of recurrent stroke Recently high-intensity interval exercise HIIE has emerged as a potentially potent stimulus that may also lead to improvements in function and fitness While HIIE has shown benefits in clinical and non-clinical populations only a few small preliminary studies have examined the effects of HIIE in individuals living with stroke and most have primarily focused on examining the effects of HIIE on function and gait No study has examined and compared the acute effects of a CPET MICE and HIIE on arterial stiffness in stroke This study will 1 examine the acute effects of a single session of this HIIE protocol compared to a CPET and a single session of MICE on arterial stiffness among individuals with chronic stroke and 2 the feasibility of a high-intensity interval training exercise protocol previously found to be tolerable and effective in attaining high levels of exercise intensity in in these individuals
Detailed Description:
Stroke is the leading cause of adult disability and the fourth leading cause of death in Canada with an annual cost to the economy of 36 billion There is an urgent need to reduce the impact of stroke by promoting optimal rehabilitation strategies that decrease the risk of stroke Improving cardiovascular health following a stroke is a key rehabilitation strategy that has the potential to reduce the risk of a recurrent event Adverse cardiovascular events including stroke are often due to chronic atherosclerosis Amplified arterial stiffness is a sign of atherosclerosis which increases arterial wall stress and reduces coronary perfusion Elevated arterial stiffness is prevalent in individuals with cardiovascular disease is associated with markers of silent cerebrovascular disease and is a new marker for predicting cardiovascular risk Cardiopulmonary exercise tests CPETs are the gold standard for assessing cardiorespiratory fitness In stroke impairments in physical function may be present and limit individuals ability to perform a CPET on traditional modes such as a cycle ergometer or treadmill Thus novel CPET protocols have been developed to allow individuals with stroke perform a fitness test safely and effectively Cardiovascular exercise typically performed through moderate-intensity continuous exercise MICE can improve function and fitness in individuals living with stroke and lower the risk of recurrent stroke Recently high-intensity interval exercise HIIE has emerged as a potentially potent stimulus that may also lead to improvements in function and fitness HIIE combines short bursts of high-intensity cardiovascular exercise with periods of rest or recovery and allows individuals to achieve higher intensities of cardiovascular exercise that do not need to be maintained for a long period of time like MICE In this way HIIE has the potential to be an additional exercise strategy to enhance cardiovascular health post-stroke While HIIE has shown benefits in clinical and non-clinical populations only a few small preliminary studies have examined the effects of HIIE in individuals living with stroke and most have primarily focused on examining the effects of HIIE on function and gait
While the chronic effects of exercise on arterial stiffness have been examined in stroke no study has examined the acute effects of a CPET MICE or HIIE Different exercise stimuli may elicit variable short-term influences on arterial stiffness in individuals who have had a stroke but this has not been previously examined The feasibility of HIIE for individuals with a broader range of functional abilities after stroke is also not well established
This study will 1 compare the acute effects of a HIIE session to a CPET and a session of MICE on arterial stiffness and 2 examine the feasibility of a HIIE protocol in individuals with a broad range of abilities after stroke The investigators anticipate that 1 arterial stiffness will be elevated to a greater degree immediately following HIIE compared to the CPET and MICE and will remain elevated following 15 minutes post-exercise and 2 both HIIE and MICE protocols will be safe and feasible for individuals with stroke no occurrence of adverse events however the HIIE protocol will allow participants to obtain and be able to sustain a higher level of exercise intensity and therefore a higher heart rate compared to MICE Understanding the time course of changes in arterial stiffness following acute exercise may provide insight into vascular responses of HIIE and thus potential underlying physiological mechanisms of post-stroke exercise
While the chronic effects of exercise on arterial stiffness have been examined in stroke no study has examined the acute effects of a CPET MICE or HIIE Different exercise stimuli may elicit variable short-term influences on arterial stiffness in individuals who have had a stroke but this has not been previously examined The feasibility of HIIE for individuals with a broader range of functional abilities after stroke is also not well established
This study will 1 compare the acute effects of a HIIE session to a CPET and a session of MICE on arterial stiffness and 2 examine the feasibility of a HIIE protocol in individuals with a broad range of abilities after stroke The investigators anticipate that 1 arterial stiffness will be elevated to a greater degree immediately following HIIE compared to the CPET and MICE and will remain elevated following 15 minutes post-exercise and 2 both HIIE and MICE protocols will be safe and feasible for individuals with stroke no occurrence of adverse events however the HIIE protocol will allow participants to obtain and be able to sustain a higher level of exercise intensity and therefore a higher heart rate compared to MICE Understanding the time course of changes in arterial stiffness following acute exercise may provide insight into vascular responses of HIIE and thus potential underlying physiological mechanisms of post-stroke exercise
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None