Ignite Creation Date:
2024-05-06 @ 11:39 AM
Last Modification Date:
2024-10-26 @ 12:48 PM
Study NCT ID:
NCT03577444
Status:
COMPLETED
Last Update Posted:
2019-08-08
First Post:
2018-06-08
Brief Title:
Role of Genetic Polymorphism in Neuroplasticity Involved in Dysphagia Recovery
Sponsor:
The Catholic University of Korea
Organization:
The Catholic University of Korea
Study Overview
Official Title:
Role of Genetic Polymorphism in Neuroplasticity Involved in Dysphagia Recovery
Status:
COMPLETED
Status Verified Date:
2019-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to assess the association of genetic polymorphism such as the Brain-derived Neurotrophic factor BDNF in neurogenic dysphagia in those with brain lesion
Detailed Description:
Neurogenic dysphagia attributable to acquired brain lesions such as after stroke and after traumatic brain injury are one of leading causes of chronic disability world widely and it is expected to substantially increase over the next two decades Among various sequalae dysphagia can be observed in about 40 -60 of post-stroke patients and 20 -30 of them might suffer from recurrent aspiration pneumonia and may inhibit recovery and can even lead to death Recovery after brain lesions can be explained by specific molecular events It is proven that Genetic polymorphisms associated with impaired neural repair or plasticity might reduce recovery from stroke Not only for the motor recovery but genetic polymorphism is also crucial for the recovery of swallowing after stroke however only limited amount of studies are available Therefore it is urgent to determine whether the recovery of swallowing disorders after stroke is affected by the inherent polymorphism of the patient whether the degree of recovery and brain plasticity associated with swallowing depend on the gene characteristics and polymorphism of the patient and whether recovery in swallowing parallel to the recovery observed in other functional areas ie hand recovery truncal control recovery ADL recovery
Based on the results of this study results will be expected to help provide genetically tailored diagnosis and prognostication according to the gene polymorphism of the patient Optimized treatment of the patient is expected to contribute to prevention of respiratory complications and improve functional outcome related to swallowing after stroke
Based on the results of this study results will be expected to help provide genetically tailored diagnosis and prognostication according to the gene polymorphism of the patient Optimized treatment of the patient is expected to contribute to prevention of respiratory complications and improve functional outcome related to swallowing after stroke
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None