Ignite Creation Date:
2024-05-05 @ 4:45 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00303420
Status:
TERMINATED
Last Update Posted:
2008-12-19
First Post:
2006-03-15
Brief Title:
Alteplase for Blood Flow Restoration in Hemodialysis Catheters
Sponsor:
University of Manitoba
Organization:
University of Manitoba
Study Overview
Official Title:
Alteplase for Blood Flow Restoration in Hemodialysis Catheters A Randomized Prospective Clinical Trial
Status:
TERMINATED
Status Verified Date:
2008-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Unable to enrol enough people to achieve the full sample size
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We are investigating a new way of administering alteplase to remove clots from hemodialysis catheters Currently alteplase is left to dwell inside the catheter between dialysis treatments to dissolve the clot and restore blood flow through the catheter We have developed a new way to administer alteplase by advancing it to the tip of the catheter at regular 10 minute intervals We hypothesize that our new push protocol will dissolve clots in hemodialysis catheters better and faster than the current dwell method
Detailed Description:
Central venous catheters are commonly used for vascular access in the hemodialysis population A common complication is low no blood flow through the catheter due to clots These are serious situations because patients may miss dialysis sessions and suffer significant morbidity In an attempt to dissolve the clots and restore blood flow thrombolytics are frequently instilled into the catheters between dialysis sessions However we have developed and new push protocol that advances fresh thrombolytic alteplase to the tip of the catheter in order to facilitate more effective and faster removal of the clot We hypothesize that our new push protocol will dissolve clots in hemodialysis catheters better and faster than the current dwell method
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None