Ignite Creation Date:
2024-05-06 @ 11:37 AM
Last Modification Date:
2024-10-26 @ 12:48 PM
Study NCT ID:
NCT03568773
Status:
COMPLETED
Last Update Posted:
2020-07-31
First Post:
2018-05-03
Brief Title:
Influence of Genetic and Physiological in Weight Loss
Sponsor:
Federal University of Paraíba
Organization:
Federal University of Paraíba
Study Overview
Official Title:
Influence of Polymorphysms in the Fto and Ppar Gen Genes Systemic Inflammation and Oxidative Stress in the Magnitude of Weight Loss Induced by Intermittent or Moderate Continuous High Intensity Training Programs
Status:
COMPLETED
Status Verified Date:
2020-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study focuses on the influence of polymorphism in the FTO genes rs9939609 and PPARᵧ Pro12Ala oxidative stress and systemic inflammation on changes in body composition and rest metabolism induced by HIIT and continuous aerobic programs in obese or overweight individuals
Detailed Description:
Although the positive effects of continuous aerobic training are already well documented in the literature on health aspects The weight loss induced by physical training is still very discrete when compared to other antiobesity means Studies demonstrate an important variability in responses to physical exercise indicating that individuals respond more or less to weight loss Among these aspects the factors that may influence exercise-induced weight loss have not yet been elucidated Thus the objective of the study is to analyze the influence of polymorphism in the genes FTO rs9939609 and PPARᵧ Pro12Ala oxidative stress and systemic inflammation on changes in body composition and rest metabolism induced by continuous and continuous aerobic programs Healthy individuals with overweight and or obesity aged 20-45 years were randomly assigned to three groups Continuous Aerobic AC Intermittent High Intensity Training HIIT and Control Group CG Groups AC and HIIT engaged in a 12-week program Before the start of the program at the sixth week and 48 hours after the intervention they performed blood collections ergospirometry dual X-ray densitometry DEXA nutritional assessments In addition collection of buccal mucosa was performed for genotyping of polymorphisms studied Initial differences between the groups as well as between the dependent variables studied will be assessed using the two-way ANOVA test or its non-parametric equivalent Correlation and regression tests will be performed to verify the influence of the independent variables and the magnitude of the exercise-induced weight loss according to the normality of the data or differences between the standard deviations The hypothesis tested is that genetic and physiological factors influence the weight loss independent of the training modality
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None