Ignite Creation Date:
2024-05-06 @ 11:35 AM
Last Modification Date:
2024-10-26 @ 12:47 PM
Study NCT ID:
NCT03550729
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2024-04-22
First Post:
2018-05-25
Brief Title:
Effects of Physical Training on Vascular Function as a Therapeutic Target in Pulmonary Hypertension
Sponsor:
Hospital Clinic of Barcelona
Organization:
Hospital Clinic of Barcelona
Study Overview
Official Title:
Effects of Physical Training on Vascular Function as a Therapeutic Target in Pulmonary Hypertension
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The role of physical training in the treatment of pulmonary arterial hypertension PAH is controversial The aim of the project is to evaluate the effect of physical training on markers of endothelial function and integrity and to identify those biomarkers associated with a better therapeutic response in patients with PAH and in an experimental model of pulmonary hypertension Methodology 1 Study in humans sample size will be 50 patients with PAH Responders and non-responders will be identified for a 12-week resistance training program Before and after the physical training program endothelial microparticles and circulating vascular progenitor cells and metabolomic and mitochondrial function parameters in circulating endothelial cells will be analyzed Patients will be identified in whom a more favorable response to the training program is obtained Additionally investigators will evaluate the relationship between this response and the biomarkers both at baseline and their change with the training program 2 Study in a murine experimental model investigators will study mice with pulmonary hypertension induced by the administration of Semaxanib SU5416 and exposure to hypoxia for 3 weeks and control mice Half of them will exercise on a treadmill for 3 weeks At the end of the program the right ventricular pressure will be measured and the animals will be sacrificed Morphometric studies in pulmonary and cardiac tissue pulmonary endothelial function and metabolomic parameters in cardiac and skeletal muscle will be performed Differences in these variables between the different experimental groups will be analyzed
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None