Ignite Creation Date:
2024-05-06 @ 11:32 AM
Last Modification Date:
2024-10-26 @ 12:47 PM
Study NCT ID:
NCT03549182
Status:
UNKNOWN
Last Update Posted:
2020-12-22
First Post:
2018-02-05
Brief Title:
Serotonin Serotonin GeneticsTPH2 and Emotion and Interference Processing
Sponsor:
University of Electronic Science and Technology of China
Organization:
University of Electronic Science and Technology of China
Study Overview
Official Title:
The Influence of Acute Tryptophan Depletion on Emotion and Interference Processing and Potential Moderation by 5HT Genetics TPH2
Status:
UNKNOWN
Status Verified Date:
2020-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study aims to explore whether acute tryptophan depletion can affect the emotion and interference processing whether this effect is moderated by the TPH2 genotype
Detailed Description:
Based on previous studies suggesting that serotonin a neurotransmitter is associated with social emotional behavior including emotional reactivity and emotion regulation the present study aims to explore effects of acute tryptophan depletion ATD on emotion processing and emotional interference processing within a randomized double-blind with-subject placebo-controlled pharmaco-fMRI experiment To further examine the potential moderating effects of the genetic makeup of the serotonin system the present study will include a pharmacogenetics imaging approach Given that TPH2 is the key regulator of the serotonergic signaling pathway we therefore assessed whether such the effects of tryptophan depletion vary according to the TPH2 genotype To this end healthy male TPH2-GG or TPH2-TT carriers will be recruited and will receive ATD 100g and placebo 1023g in a within subject design To control for potential effects of pre-medication personality traits as well as effects of medicines on mood subjects will be administered pre-treatment assessing relevant personality traits and post-treatment assessments of mood
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None