Ignite Creation Date:
2024-05-05 @ 4:44 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00305136
Status:
COMPLETED
Last Update Posted:
2017-10-11
First Post:
2006-03-19
Brief Title:
Advancement of Psychophysics of Pain Modulation From Lab to Clinic Constructing Susceptibility Profile for Appearance of Postoperative Neuropathic Pain
Sponsor:
Rambam Health Care Campus
Organization:
Rambam Health Care Campus
Study Overview
Official Title:
Advancement of Psychophysics of Pain Modulation From Lab to Clinic Constructing Susceptibility Profile for Appearance of Postoperative Neuropathic Pain
Status:
COMPLETED
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Recent advances in the field of pain psychophysics that have enhanced the understanding of pain processing by the nervous system seem to characterize the individual pattern of pain processing thereby enabling the prediction of a persons susceptibility to develop chronic pain consequent to surgery
In this project the researchers propose to apply a wide array of advanced testing methods in order to prospectively assess the pain modulation pattern of pain free patients about to undergo an elective thoracotomy Since about half of post-thoracotomy patients suffer from chronic neuropathic postoperative pain the researchers expect to identify which tests predict a risk for this pain and the relative power of the relevant tests in this prediction and to construct a short and applicable tool the pain susceptibility profile that will reliably predict the risk for the development of pain The expected results of this project will serve the field of pain prevention by identifying patients at risk and tailoring interventions to reduce the risk of chronic pain
In this project the researchers propose to apply a wide array of advanced testing methods in order to prospectively assess the pain modulation pattern of pain free patients about to undergo an elective thoracotomy Since about half of post-thoracotomy patients suffer from chronic neuropathic postoperative pain the researchers expect to identify which tests predict a risk for this pain and the relative power of the relevant tests in this prediction and to construct a short and applicable tool the pain susceptibility profile that will reliably predict the risk for the development of pain The expected results of this project will serve the field of pain prevention by identifying patients at risk and tailoring interventions to reduce the risk of chronic pain
Detailed Description:
The common prevalence of painful syndromes following surgical interventions and injuries calls for a preventive therapeutic approach that can only be based on better insight into the pain modulation mechanisms in these patients Recent advances in the field of pain psychophysics that have enhanced our understanding of pain processing by the nervous system seem to characterize the individual pattern of pain processing thereby enabling the prediction of a persons susceptibility to develop chronic pain consequent to surgery
In this project we propose to apply a wide array of advanced testing methods in order to prospectively assess the pain modulation pattern of pain free patients about to undergo an elective thoracotomy Tests will include
1 psychophysical tests pain thresholds and suprathreshold magnitude estimation temporal summation endogenous analgesia - diffuse noxious inhibitory control DNIC
2 tests for the interaction between pain and the autonomic nervous system including the inhibitory effect of vagal activation on pain perception and the response pattern of the sympatho-parasympathetic balance to noxious stimulation and
3 evaluation of personality components known to be associated with chronic pain including anxiety catastrophization and somatization
Since about half of post-thoracotomy patients suffer from chronic neuropathic postoperative pain we expect to identify which tests predict a risk for this pain and the relative power of the relevant tests in this prediction and to construct a short and applicable tool the pain susceptibility profile that will reliably predict the risk for the development of pain The contribution of the above tests to the severity of acute postoperative pain and of the latter on the development of the chronic postoperative pain will also be evaluated
The expected results of this project will serve pain prevention by identifying patients at risk and tailoring interventions to reduce the risk of chronic pain Also in the wider pain research context this understanding will allow better design and analysis of studies on pain mechanisms and therapies by considering the pain susceptibility of participating patients
In this project we propose to apply a wide array of advanced testing methods in order to prospectively assess the pain modulation pattern of pain free patients about to undergo an elective thoracotomy Tests will include
1 psychophysical tests pain thresholds and suprathreshold magnitude estimation temporal summation endogenous analgesia - diffuse noxious inhibitory control DNIC
2 tests for the interaction between pain and the autonomic nervous system including the inhibitory effect of vagal activation on pain perception and the response pattern of the sympatho-parasympathetic balance to noxious stimulation and
3 evaluation of personality components known to be associated with chronic pain including anxiety catastrophization and somatization
Since about half of post-thoracotomy patients suffer from chronic neuropathic postoperative pain we expect to identify which tests predict a risk for this pain and the relative power of the relevant tests in this prediction and to construct a short and applicable tool the pain susceptibility profile that will reliably predict the risk for the development of pain The contribution of the above tests to the severity of acute postoperative pain and of the latter on the development of the chronic postoperative pain will also be evaluated
The expected results of this project will serve pain prevention by identifying patients at risk and tailoring interventions to reduce the risk of chronic pain Also in the wider pain research context this understanding will allow better design and analysis of studies on pain mechanisms and therapies by considering the pain susceptibility of participating patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| ISF | None | None | None |