Ignite Creation Date:
2024-05-05 @ 4:44 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00301249
Status:
COMPLETED
Last Update Posted:
2020-04-28
First Post:
2006-03-09
Brief Title:
The Family Investigation of Nephropathy and Diabetes Study
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Study Overview
Official Title:
The Family Investigation of Nephropathy and Diabetes FIND Study
Status:
COMPLETED
Status Verified Date:
2020-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FIND
Brief Summary:
The Family Investigation of Nephropathy and Diabetes FINDStudy is a multi-center consortium The charge of the consortium is to acquire sets of families with well-characterized diabetic nephropathy establish a secure master FIND database and perform a genome scan to identify chromosomal regions linked with diabetic nephropathy
Detailed Description:
Diabetic Nephropathy DN is undoubtedly a multifactorial disease and a large proportion of patients affected with either type 1 or type 2 diabetes develop diabetic nephropathy and progress to end stage renal disease ESRD When poor prognostic factors such as hypertension and chronic hyperglycemia are aggressively treated the rate of progression of diabetic nephropathy can be slowed However no interventions have been shown to reliably halt the progression of diabetic nephropathy Numerous studies have suggested that genetic predisposition to diabetic nephropathy exists but genes for nephropathy have not yet been isolated It is anticipated that a comprehensive analysis of a large number of uniformly phenotyped ESRD families will be necessary to isolate genes for ESRD Such a database of families may not be available at any single institution The FIND study has established a centralized Genetic Analysis and Data Coordinating Center GADCC that together with eight participating investigation centers PICs three minority recruitment centers and the National Institute of Diabetes Digestive and Kidney Diseases NIDDK will use the emerging high-throughput genetic technologies to enable identification of diabetic nephropathy susceptibility or protection genes The charge of the consortium is to acquire sets of families with well-characterized diabetic nephropathy establish a secure master FIND database and perform a genome scan to identify chromosomal regions linked with diabetic nephropathy The FIND study population includes participants from European American EA Native American NA African American AA and Mexican American AA populations
Two analytic approaches are utilized in FIND The Family Study approach involves the enrollment of probands affected or discordant sibling and their affected family members Analytic methods include affected sibling pair ASP discordant sibling pair DSP affected relative pair ARP and discordant relative pair DRP linkage analyses for the Family Study The Mapping by Admixture and Linkage Disequilibrium MALD approach involves the enrollment of probands and a population based control for both the AA and MA studies In addition a spousal control diad and when available a child 18 years or older will be recruited triadfor the AA MALD study only
Two analytic approaches are utilized in FIND The Family Study approach involves the enrollment of probands affected or discordant sibling and their affected family members Analytic methods include affected sibling pair ASP discordant sibling pair DSP affected relative pair ARP and discordant relative pair DRP linkage analyses for the Family Study The Mapping by Admixture and Linkage Disequilibrium MALD approach involves the enrollment of probands and a population based control for both the AA and MA studies In addition a spousal control diad and when available a child 18 years or older will be recruited triadfor the AA MALD study only
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U01DK057292 | NIH | None | httpsreporternihgovquickSearchU01DK057292 |