Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005224
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Gender Response To Coronary Risk
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine sex differences in behavioral and psychosocial variables such as occupation Type A behavior and hostility as they related to primary coronary risk factors
Detailed Description:
BACKGROUND
Although coronary heart disease is a major factor in morbidity and mortality in both sexes most studies prior to 1988 when the study was initiated focused on men and overlooked the magnitude of the problem in women Coronary heart disease mortality and morbidity rates are higher in men than in women accounting for 41 percent of the sex difference in overall mortality in the United States Womens advantage however does not seem to be stable over time nor universal For example in 1920 the age adjusted ratio of male to female coronary heart disease deaths was approximately equal but between 1975 and 1978 it has increased to a level of 247 in the United States Also sex mortality ratios for heart disease differ widely across countries ranging from 51 in Finland to 1871 in Yugoslavia Thus relying on biological differences alone when explaining this sex differential is not convincing
Based on Framingham data among the most important risk factors predicting coronary heart disease in both women and men are--aside from age--cholesterol cigarette smoking and blood pressure Consistent with the observation that men are more likely to fall victim to coronary heart disease than women is the fact that they also exhibit higher levels of these risk factors when compared to women at least up to the age of 45 Standardization of risk factor levels and controlling for both levels of risk factors on coronary heart disease probabilities eliminated the sex differential in 45 to 54 year olds of the Framingham Study However among the 55 to 74 year olds the sex differential was not due to differences in levels or impact of the risk factors It was conceivable that the sex mortality differential at the older ages was due to the sex differential in primary coronary risk factors at the younger ages
Of particular interest was the fact that the primary risk factors appeared to be influenced by behavior It was possible that gender differences in behavior might explain gender differences in primary coronary risk factors Alternatively there was some evidence that the primary coronary risk factors were not solely responsible for the etiology of coronary heart disease Gender differences in psychosocial variables such as Type A behavior hostility and occupational stress that might play independent roles in the etiology of coronary heart disease had not been systematically investigated
DESIGN NARRATIVE
Gender differences in primary risk factors were determined with all analyses being controlled for body mass since men score higher on body mass index than women and body mass is related to levels of primary coronary risk factors One-way analyses of covariance were performed for plasma lipids and lipoproteins blood pressure and heart rate Gender differences in psychosocial variables associated with coronary risk were investigated Analyses were performed on primary coronary risk factors at baseline in order to investigate the relationships of occupational characteristics such as demand and control with age and body mass index Covariance analyses were performed for Type AType B by high and low occupational control and by high and low demand for each sex The role of parental history of heart disease Type A behavior and smoking in elevated primary coronary risk factors among oral contraceptive users were also investigated
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Although coronary heart disease is a major factor in morbidity and mortality in both sexes most studies prior to 1988 when the study was initiated focused on men and overlooked the magnitude of the problem in women Coronary heart disease mortality and morbidity rates are higher in men than in women accounting for 41 percent of the sex difference in overall mortality in the United States Womens advantage however does not seem to be stable over time nor universal For example in 1920 the age adjusted ratio of male to female coronary heart disease deaths was approximately equal but between 1975 and 1978 it has increased to a level of 247 in the United States Also sex mortality ratios for heart disease differ widely across countries ranging from 51 in Finland to 1871 in Yugoslavia Thus relying on biological differences alone when explaining this sex differential is not convincing
Based on Framingham data among the most important risk factors predicting coronary heart disease in both women and men are--aside from age--cholesterol cigarette smoking and blood pressure Consistent with the observation that men are more likely to fall victim to coronary heart disease than women is the fact that they also exhibit higher levels of these risk factors when compared to women at least up to the age of 45 Standardization of risk factor levels and controlling for both levels of risk factors on coronary heart disease probabilities eliminated the sex differential in 45 to 54 year olds of the Framingham Study However among the 55 to 74 year olds the sex differential was not due to differences in levels or impact of the risk factors It was conceivable that the sex mortality differential at the older ages was due to the sex differential in primary coronary risk factors at the younger ages
Of particular interest was the fact that the primary risk factors appeared to be influenced by behavior It was possible that gender differences in behavior might explain gender differences in primary coronary risk factors Alternatively there was some evidence that the primary coronary risk factors were not solely responsible for the etiology of coronary heart disease Gender differences in psychosocial variables such as Type A behavior hostility and occupational stress that might play independent roles in the etiology of coronary heart disease had not been systematically investigated
DESIGN NARRATIVE
Gender differences in primary risk factors were determined with all analyses being controlled for body mass since men score higher on body mass index than women and body mass is related to levels of primary coronary risk factors One-way analyses of covariance were performed for plasma lipids and lipoproteins blood pressure and heart rate Gender differences in psychosocial variables associated with coronary risk were investigated Analyses were performed on primary coronary risk factors at baseline in order to investigate the relationships of occupational characteristics such as demand and control with age and body mass index Covariance analyses were performed for Type AType B by high and low occupational control and by high and low demand for each sex The role of parental history of heart disease Type A behavior and smoking in elevated primary coronary risk factors among oral contraceptive users were also investigated
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL040368 | NIH | None | httpsreporternihgovquickSearchR01HL040368 |