Ignite Creation Date:
2024-05-05 @ 4:44 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00306579
Status:
COMPLETED
Last Update Posted:
2017-08-08
First Post:
2006-03-23
Brief Title:
Myocardial Damage In Patients With Cerebral Infarction
Sponsor:
Danish Heart Foundation
Organization:
Danish Heart Foundation
Study Overview
Official Title:
Myocardial Damage In Patients With Cerebral Infarction Prevalence and Characteristics as Measured by Troponins Electrocardiographic Changes and Myocardial Perfusion Imaging
Status:
COMPLETED
Status Verified Date:
2017-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction
For several years ischemic electrocardiographic ECG changes in the acute phase of ischemic stroke have been reported Whether these ECG changes reflect true myocardial ischemia remains controversial So far no study has assessed different markers of myocardial ischemia or necrosis in consecutive patients admitted to hospital with an acute ischemic stroke
Purpose
The main purpose of this study is to determine the potential burden of reversible and irreversible myocardial ischemia in patients with an acute ischemic stroke
Patients and methods
Serial blood samples for measuring troponin T CK-MB and NT-proBNP are collected in 250 patients with evidence of an acute ischemic stroke admitted to the Department of Neurology at Odense University Hospital In addition resting 12-lead ECG recordings will be obtained on a daily basis and a 24-hour ST-segment ambulatory monitoring will be performed once within the first week of hospitalisation Finally myocardial perfusion patterns during rest will be evaluated by means of a myocardial perfusion scintigraphy in patients with an elevated troponin T level
Six months later control measurements of troponin T CK-MB and NT-proBNP and a 12-lead ECG will be obtained
Expectations
The study will contribute with original observations in patients with acute ischemic stroke considering the following issues
1 The prevalence and characteristics of ECG changes suggestive of myocardial ischemia
2 The prevalence of transient ST-segment changes on ambulatory monitoring
3 The prevalence and degree of myocardial necrosis as judged from biochemical markers
4 The prevalence of reversible and irreversible perfusion defects on myocardial scintigraphy
5 The prevalence size and patterns of NT-proBNP
6 Whether there is a change in ECG and biochemical markers over a 6-month follow-up period
The results may have clinical implications regarding early and late treatment as well as clinical follow-up of patients recovering from an episode of acute ischemic stroke
For several years ischemic electrocardiographic ECG changes in the acute phase of ischemic stroke have been reported Whether these ECG changes reflect true myocardial ischemia remains controversial So far no study has assessed different markers of myocardial ischemia or necrosis in consecutive patients admitted to hospital with an acute ischemic stroke
Purpose
The main purpose of this study is to determine the potential burden of reversible and irreversible myocardial ischemia in patients with an acute ischemic stroke
Patients and methods
Serial blood samples for measuring troponin T CK-MB and NT-proBNP are collected in 250 patients with evidence of an acute ischemic stroke admitted to the Department of Neurology at Odense University Hospital In addition resting 12-lead ECG recordings will be obtained on a daily basis and a 24-hour ST-segment ambulatory monitoring will be performed once within the first week of hospitalisation Finally myocardial perfusion patterns during rest will be evaluated by means of a myocardial perfusion scintigraphy in patients with an elevated troponin T level
Six months later control measurements of troponin T CK-MB and NT-proBNP and a 12-lead ECG will be obtained
Expectations
The study will contribute with original observations in patients with acute ischemic stroke considering the following issues
1 The prevalence and characteristics of ECG changes suggestive of myocardial ischemia
2 The prevalence of transient ST-segment changes on ambulatory monitoring
3 The prevalence and degree of myocardial necrosis as judged from biochemical markers
4 The prevalence of reversible and irreversible perfusion defects on myocardial scintigraphy
5 The prevalence size and patterns of NT-proBNP
6 Whether there is a change in ECG and biochemical markers over a 6-month follow-up period
The results may have clinical implications regarding early and late treatment as well as clinical follow-up of patients recovering from an episode of acute ischemic stroke
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None