Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005361
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Determinants of Respiratory Health in Young Adults
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To measure lung function and respiratory symptom status in a large cohort of healthy non-smoking 18-22 year old subjects and relate these measurements to past histories of passive smoke and air pollution exposures
Detailed Description:
BACKGROUND
While the natural history of human lung function growth and decline has been studied intensively over the past 30 years relatively few data have been collected during the period in which peak volumetric function is achieved ie around the age of 20 As a result very little is known about the factors both demographic and environmental which influence maximal attained lung function
DESIGN NARRATIVE
The longitudinal study collected information on the history of respiratory illness residential history parental smoking socio-economic status and home characteristics via an initial questionnaire administered to cadets enrolling at West Point A sequence of four annual measurements of lung function by spirometry and prior-year respiratory health status and activity patterns was obtained in the spring of each year Pollution exposures were estimated by matching residential histories with historical pollution data stored at the Environmental Protection Agency Data on meteorological variables temperature relative humidity wind speed and altitude were obtained for each residential location The four annual lung function measurements provided precise estimates of individual mean levels of FVC FEV1 FEF25-75 PEFR and flow rates at 50 percent and 75 percent of expired FVC Subject-specific lung function level was analyzed in relation to history of parental smoking and prior exposure to air pollution using analysis of variance methods controlling for potential confounding variables In addition to testing these hypotheses regarding the respiratory effects of passive smoking and air pollution exposure the study also explored the effects of these exposures on the change in lung function between the ages of 18 and 22 and on respiratory illness and symptom experience while at West Point Finally the study established a cohort which could be followed in future years
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
While the natural history of human lung function growth and decline has been studied intensively over the past 30 years relatively few data have been collected during the period in which peak volumetric function is achieved ie around the age of 20 As a result very little is known about the factors both demographic and environmental which influence maximal attained lung function
DESIGN NARRATIVE
The longitudinal study collected information on the history of respiratory illness residential history parental smoking socio-economic status and home characteristics via an initial questionnaire administered to cadets enrolling at West Point A sequence of four annual measurements of lung function by spirometry and prior-year respiratory health status and activity patterns was obtained in the spring of each year Pollution exposures were estimated by matching residential histories with historical pollution data stored at the Environmental Protection Agency Data on meteorological variables temperature relative humidity wind speed and altitude were obtained for each residential location The four annual lung function measurements provided precise estimates of individual mean levels of FVC FEV1 FEF25-75 PEFR and flow rates at 50 percent and 75 percent of expired FVC Subject-specific lung function level was analyzed in relation to history of parental smoking and prior exposure to air pollution using analysis of variance methods controlling for potential confounding variables In addition to testing these hypotheses regarding the respiratory effects of passive smoking and air pollution exposure the study also explored the effects of these exposures on the change in lung function between the ages of 18 and 22 and on respiratory illness and symptom experience while at West Point Finally the study established a cohort which could be followed in future years
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL048619 | NIH | None | httpsreporternihgovquickSearchR01HL048619 |