Ignite Creation Date:
2024-05-05 @ 4:43 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00308776
Status:
TERMINATED
Last Update Posted:
2012-05-28
First Post:
2006-03-28
Brief Title:
Cholecystokinin for Reducing Binge Eating in People With Bulimia Nervosa
Sponsor:
New York State Psychiatric Institute
Organization:
New York State Psychiatric Institute
Study Overview
Official Title:
Effect of Cholecystokinin on Binge Eating in Bulimia Nervosa
Status:
TERMINATED
Status Verified Date:
2012-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Unable to recruit subjects
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine the effectiveness of administrating a dose of cholecystokinin during a binge eating episode in reducing this eating behavior in people with bulimia nervosa
Detailed Description:
Bulimia Nervosa BN is a serious eating disorder that is characterized by frequent uncontrolled eating binges These binges are often followed by compensatory behavior including the following self-induced vomiting misuse of laxatives diuretics enemas or other medications to induce purging fasting or excessive exercise If left untreated BN can lead to many serious health issues tooth decay irregular menstruation bowel damage constipation heart and kidney disease intestinal damage puffiness especially in the face and fingers increased hair growth on the face and body and mineral imbalances in the body Cholecystokinin CCK is a hormone that is released by the small intestine and functions as a trigger for digestion and hunger suppression People with BN often have disturbances in the release of CCK which may contribute to their binge eating behavior This study will determine the effectiveness of administrating a dose of CCK during a binge eating episode in reducing this eating behavior in people with BN
This study will enroll females with BN and healthy females without BN Interested participants will first report to the study site for an interview about their feelings on their eating habits If eligible participants will report to the study site at 9 AM on 4 days Upon arrival they will receive a standardized breakfast of apple juice and an English muffin with butter Participants will then return 25 hours later to start an IV and begin infusion with a normal saline solution After 10 minutes of saline infusion participants will eat a small bowl of tomato soup followed 20 minutes later by a 15-minute infusion of either saline or saline plus CCK Participants will then be given a meal of macaroni and beef They will be alone in the room while eating but will be monitored by TV camera Nothing however will be taped or recorded A tape recording will be used to instruct participants when to begin eating Participants will be instructed to either eat until an assistant returns to the room or eat as much as they can Participants will also fill out questionnaires before and after each meal and sometimes during a meal The amount of food consumed after an infusion with CCK will be assessed upon study completion
For information on related studies please follow these links
httpclinicaltrialsgovshowNCT00307190
httpclinicaltrialsgovshowNCT00304187
This study will enroll females with BN and healthy females without BN Interested participants will first report to the study site for an interview about their feelings on their eating habits If eligible participants will report to the study site at 9 AM on 4 days Upon arrival they will receive a standardized breakfast of apple juice and an English muffin with butter Participants will then return 25 hours later to start an IV and begin infusion with a normal saline solution After 10 minutes of saline infusion participants will eat a small bowl of tomato soup followed 20 minutes later by a 15-minute infusion of either saline or saline plus CCK Participants will then be given a meal of macaroni and beef They will be alone in the room while eating but will be monitored by TV camera Nothing however will be taped or recorded A tape recording will be used to instruct participants when to begin eating Participants will be instructed to either eat until an assistant returns to the room or eat as much as they can Participants will also fill out questionnaires before and after each meal and sometimes during a meal The amount of food consumed after an infusion with CCK will be assessed upon study completion
For information on related studies please follow these links
httpclinicaltrialsgovshowNCT00307190
httpclinicaltrialsgovshowNCT00304187
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DATR A2-AID | None | None | None |