Ignite Creation Date:
2024-05-05 @ 4:43 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00302588
Status:
UNKNOWN
Last Update Posted:
2006-03-14
First Post:
2006-03-12
Brief Title:
The Final Diagnosis and Treatment Result of Metastatic Cervical Carcinoma of Unknown Primary
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2005-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Investigate the final diagnosis and treatment result of metastatic cervical carcinoma of unknown primary
Detailed Description:
Carcinoma of unknown primary CUP is defined as biopsy-proven metastasis of an epithelial malignancy in the absence of an identifiable primary site after complete history and physical examination basic laboratory studies chest X-ray and additional directed studies indicated by positive findings during the initial work-up It is characterized by its slow local development and its high metastatic potential12 Patients with CUP represent 4-10 of all new cancer patients34 The presenting sites of metastasis identified pathologically radiographically or by physical examination were found most frequently in the lymph nodes 371 followed by the liver bone lung pleurapleural space brain peritoneum adrenal and skin Of the lymph nodes of metastasis the supraclavicular cervical area is the leading site 313 followed by the mediastinum axilla retroperitonium and inguina5 The incidence of metastatic cervical CUP MCCUP varies between 2 and 9 of all head and neck cancers6-8 The level of cervical metastatic involvement may give some clue as to the likely primary site A submandibular mass level I would most commonly be related to a primary in the oral cavity or skin Level II nodes including the jugulodigastric node may point to a primary in the oral cavity oropharynx or supraglottic larynx Tumours of the nasopharynx generally spread to level II or the posterior triangle as well as retropharyngeal nodes Middle and lower jugular nodes levels III and IV are more likely related to a laryngeal or hypopharyngeal cancer Metastatic disease restricted to the supraclavicular region is often due to an infraclavicular primary site9 The prognosis is different according to the involved lymph node level and possible primary site Modern cancer management relies heavily on recognition of the primary tumor thus the absence of a primary site poses major diagnostic and therapeutic problems The patient benefits from identification of the initial tumor site because postoperative irradiation ports may be reduced and because surveillance for recurrence may be improved10 In order to identify the likely primary site of MCCUP and compare the prognoses of known and unknown primary groups we report the results according to the different levels of metastatic cervical lymph nodes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None