Ignite Creation Date:
2024-05-05 @ 4:43 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00303160
Status:
UNKNOWN
Last Update Posted:
2007-08-14
First Post:
2006-03-14
Brief Title:
Effect of Helicobacter Pylori on the Availability of Vitamin E and C
Sponsor:
University of Toronto
Organization:
University of Toronto
Study Overview
Official Title:
Effect of Helicobacter Pylori on the Availability of Vitamin E and C
Status:
UNKNOWN
Status Verified Date:
2007-08
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study argues that Hpylori infection by increasing the production of reactive oxygen species increases the utilization of dietary antioxidantsVit E and Vit C that serve in quenching the free radicals thus decreasing their serum levels and confounding their protective effect against gastric cancer
Detailed Description:
It has been postulated that dietary antioxidants may reduce cancer risk by modulating red-ox status by preventing biological oxidation and by inhibiting the formation of carcinogen However supplementation studies and prospective studies have yielded contradictory results In the case of gastric cancer Hpylori infection which is known to be associated with a higher risk of the disease results in an increased production of ROS RNS As a result serum levels of these free radicals increase exerting a higher demand for dietary antioxidants to neutralize them
The fact that the relation between serum levels of antioxidants and gastric cancer is more consistent than that of dietary intake levels and the disease suggests the possibility of the presence of an intrinsic factor that is altering the true relation between dietary antioxidants and the cancer This intrinsic factor this study argues is the infection with Hpylori
Hpylori infection by increasing the production of reactive oxygen species increases the utilization of dietary antioxidants that serve in quenching the free radicals thus decreasing their serum levels and confounding their protective effect against gastric cancer The purpose of this pilot study is to investigate the possibility that Hpylori infection alters the bioavailability of the dietary antioxidants vitamin C and vitamin E This project will be done in preparation for an etiologic study of dietary antioxidants and gastric cancer
The fact that the relation between serum levels of antioxidants and gastric cancer is more consistent than that of dietary intake levels and the disease suggests the possibility of the presence of an intrinsic factor that is altering the true relation between dietary antioxidants and the cancer This intrinsic factor this study argues is the infection with Hpylori
Hpylori infection by increasing the production of reactive oxygen species increases the utilization of dietary antioxidants that serve in quenching the free radicals thus decreasing their serum levels and confounding their protective effect against gastric cancer The purpose of this pilot study is to investigate the possibility that Hpylori infection alters the bioavailability of the dietary antioxidants vitamin C and vitamin E This project will be done in preparation for an etiologic study of dietary antioxidants and gastric cancer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None