Ignite Creation Date:
2024-05-06 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 12:43 PM
Study NCT ID:
NCT03489083
Status:
COMPLETED
Last Update Posted:
2018-04-05
First Post:
2018-03-20
Brief Title:
Heat Shock Response is Blunted in Elderly Diabetic People But Recovered by Strength Training
Sponsor:
Federal University of Rio Grande do Sul
Organization:
Federal University of Rio Grande do Sul
Study Overview
Official Title:
Heat-induced Extracellular HSP72 Release is Blunted in Elderly Diabetic People in Comparison With Healthy Middle-aged and Older Adults But is Partially Restored by Strength Training
Status:
COMPLETED
Status Verified Date:
2018-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study was to compare the heat shock response HSR between healthy middle-aged adults healthy elderly adults and type 2 diabetic elderly people In addition considering the effects of strength exercise in promoting health we aimed to test the effects of strength training over the HSR in diabetic elderly people Thirty 19 females and 11 males sedentary non-smoking participants volunteered for this study 11 healthy middle-age adults 7 healthy old adults and 12 diabetic old subjects previously diagnosed by their personal physicians
Firstly venous blood samples were obtained from all participants to test the HSR They were divided in three groups healthy middle-age adults 45-59 yo healthy elderly adults and elderly diabetic 60 yo As we identify that diabetic people presented a poor HSR we submit the diabetic group to a twelve-week resistance exercise training to verify if this intervention could improve the HS response
Diabetic subjects were randomly 11 block randomization allocated in one of the two groups Trained and Control no training Strength training was performed three times per week while the control group performed a placebo stretchingrelaxing session once a week for adherence purposes Both interventions had twelve weeks of duration To avoid any significant adaptation all stretching exercises for large muscle groups only were performed at very low intensity without any significant discomfort
Supervised by qualified sport and exercise scientists exercise was performed in a gym on three non-consecutive days of the week Each session lasted 60 min and consisted of a warm up the resistance exercise training and a cool down The training programme consisted of a combination of upper and lower body exercises using gym equipments free weights and body weight as the primary resistance The twelve weeks of strength training were divided into three mesocycles of four weeks each Exercises included leg press knee extensions and leg curls biceps curls triceps extensions lat pull-downs shoulder press bench press and abdominal crunch Before the start of the training period subjects completed a familiarization session to practice the exercises they would further perform during the training sessions where the exercise load was individually tested The resistance training was performed using two to three sets per exercise at intensities between 12-15 repetition maximum-RM
Firstly venous blood samples were obtained from all participants to test the HSR They were divided in three groups healthy middle-age adults 45-59 yo healthy elderly adults and elderly diabetic 60 yo As we identify that diabetic people presented a poor HSR we submit the diabetic group to a twelve-week resistance exercise training to verify if this intervention could improve the HS response
Diabetic subjects were randomly 11 block randomization allocated in one of the two groups Trained and Control no training Strength training was performed three times per week while the control group performed a placebo stretchingrelaxing session once a week for adherence purposes Both interventions had twelve weeks of duration To avoid any significant adaptation all stretching exercises for large muscle groups only were performed at very low intensity without any significant discomfort
Supervised by qualified sport and exercise scientists exercise was performed in a gym on three non-consecutive days of the week Each session lasted 60 min and consisted of a warm up the resistance exercise training and a cool down The training programme consisted of a combination of upper and lower body exercises using gym equipments free weights and body weight as the primary resistance The twelve weeks of strength training were divided into three mesocycles of four weeks each Exercises included leg press knee extensions and leg curls biceps curls triceps extensions lat pull-downs shoulder press bench press and abdominal crunch Before the start of the training period subjects completed a familiarization session to practice the exercises they would further perform during the training sessions where the exercise load was individually tested The resistance training was performed using two to three sets per exercise at intensities between 12-15 repetition maximum-RM
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None