Ignite Creation Date:
2024-05-06 @ 11:17 AM
Last Modification Date:
2024-10-26 @ 12:43 PM
Study NCT ID:
NCT03483792
Status:
UNKNOWN
Last Update Posted:
2020-11-19
First Post:
2018-02-14
Brief Title:
Heritability of Polycystic Ovary Syndrome Role of Antimullerian Hormone Steroids and Leptin
Sponsor:
University Hospital Lille
Organization:
University Hospital Lille
Study Overview
Official Title:
Heritability of Polycystic Ovary Syndrome Role of Antimullerian Hormone Steroids and Leptin
Status:
UNKNOWN
Status Verified Date:
2020-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HERITOPK
Brief Summary:
Polycystic ovary syndrome PCOS is the most common cause of ovulation disorders and affects 10 to 15 of women Despite its frequency its physiopathology remains unknown
In women Anti-Müllerian hormone AMH is secreted by granulosa cells located in the ovaries within the follicles Compared to control women serum AMH level is higher in PCOS women and could play a role in its pathophysiology The severity of the PCOS phenotype is correlated with the production of AMH
It is currently described in the literature that daughters of women with PCOS have a 50 risk of developing PCOS but no genetic cause of transmission is known In mice article in press pregnant females injected with AMH give birth to offspring with PCOS symptoms The AMH could thus also play a role in the heritability of PCOS in women Our team demonstrated that AMH in its active cleaved form had a direct central action on the hypothalamus by increasing the pulsatility of GnRH inducing LH hypersecretion The hypothesis is that AMH remains higher in pregnant women with PCOS and may affect the fetus by altering fetal and maternal hypothalamic secretions or by modifying placental steroid production
Leptin has a role in reproduction through its receptors located at the central hypothalamus and peripheral granulosa cells levels In excessively high serum concentration as observed in obesity it would lead to a dysregulation of GnRH secretion an alteration of ovarian steroidogenesis and a dysregulation of folliculogenesis
Will be compare leptin levels in first trimester patients with and without PCOS to look for possible correlations between AMH and leptin and eliminate possible bias
In women Anti-Müllerian hormone AMH is secreted by granulosa cells located in the ovaries within the follicles Compared to control women serum AMH level is higher in PCOS women and could play a role in its pathophysiology The severity of the PCOS phenotype is correlated with the production of AMH
It is currently described in the literature that daughters of women with PCOS have a 50 risk of developing PCOS but no genetic cause of transmission is known In mice article in press pregnant females injected with AMH give birth to offspring with PCOS symptoms The AMH could thus also play a role in the heritability of PCOS in women Our team demonstrated that AMH in its active cleaved form had a direct central action on the hypothalamus by increasing the pulsatility of GnRH inducing LH hypersecretion The hypothesis is that AMH remains higher in pregnant women with PCOS and may affect the fetus by altering fetal and maternal hypothalamic secretions or by modifying placental steroid production
Leptin has a role in reproduction through its receptors located at the central hypothalamus and peripheral granulosa cells levels In excessively high serum concentration as observed in obesity it would lead to a dysregulation of GnRH secretion an alteration of ovarian steroidogenesis and a dysregulation of folliculogenesis
Will be compare leptin levels in first trimester patients with and without PCOS to look for possible correlations between AMH and leptin and eliminate possible bias
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2017-A02628-45 | OTHER | ID-RCB number ANSM | None |