Ignite Creation Date:
2024-05-05 @ 9:36 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005444
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Hypertension in Families of African Origin
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate familial patterns of hypertension and related cardiovascular CV risk factors in the United States and Nigeria
Detailed Description:
BACKGROUND
It has been known for many years that African Americans experience twofold higher rates of hypertension than do whites The underlying biological mechanisms which lead to this differential are still not understood however Despite widespread speculation that persons of African descent are genetically susceptible to hypertension few direct studies have been carried out Rates of hypertension remain low in West Africa and this study will provide a contrast between populations of similar genetic background in a low versus high risk environmental setting
DESIGN NARRATIVE
A total of 240 families were identified from completed community surveys in Maywood Illinois and Ibadan Nigeria Probands were ages 45-55 and equally divided between males and females A minimum of five first-degree relatives were examined in each family to obtain information on the following variables blood pressure BP obesity urinary sodium and potassium socioeconomic status and physical activity In addition plasma and DNA were collected and stored for future studies of relevant physiologic intermediate phenotypes and candidate genes for hypertension in the two contrasting populations These data provided the basis for examining familial aggregation of blood pressurehypertension and related CV risk factors Three primary goals were addressed 1 to determine whether the familial aggregation of blood pressure in Black populations was influenced by the overall distribution of environmental factors at the population level by contrasting the distribution of familial correlations of blood pressure and the familial aggregation of hypertension in Nigeria and the United States to determine the significance of measured environmental correlates of blood pressure by comparing the magnitude of variance components for probands and relatives in each setting and 3 to use path analysis to obtain estimates of genetic and cultural heritability of blood pressure controlling for clustering environmental factors at the household level Plasma and DNA samples collected in this study provided additional valuable resources for future molecular research
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
It has been known for many years that African Americans experience twofold higher rates of hypertension than do whites The underlying biological mechanisms which lead to this differential are still not understood however Despite widespread speculation that persons of African descent are genetically susceptible to hypertension few direct studies have been carried out Rates of hypertension remain low in West Africa and this study will provide a contrast between populations of similar genetic background in a low versus high risk environmental setting
DESIGN NARRATIVE
A total of 240 families were identified from completed community surveys in Maywood Illinois and Ibadan Nigeria Probands were ages 45-55 and equally divided between males and females A minimum of five first-degree relatives were examined in each family to obtain information on the following variables blood pressure BP obesity urinary sodium and potassium socioeconomic status and physical activity In addition plasma and DNA were collected and stored for future studies of relevant physiologic intermediate phenotypes and candidate genes for hypertension in the two contrasting populations These data provided the basis for examining familial aggregation of blood pressurehypertension and related CV risk factors Three primary goals were addressed 1 to determine whether the familial aggregation of blood pressure in Black populations was influenced by the overall distribution of environmental factors at the population level by contrasting the distribution of familial correlations of blood pressure and the familial aggregation of hypertension in Nigeria and the United States to determine the significance of measured environmental correlates of blood pressure by comparing the magnitude of variance components for probands and relatives in each setting and 3 to use path analysis to obtain estimates of genetic and cultural heritability of blood pressure controlling for clustering environmental factors at the household level Plasma and DNA samples collected in this study provided additional valuable resources for future molecular research
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R29HL052075 | NIH | None | httpsreporternihgovquickSearchR29HL052075 |