Ignite Creation Date:
2024-05-06 @ 11:15 AM
Last Modification Date:
2024-10-26 @ 12:42 PM
Study NCT ID:
NCT03476629
Status:
UNKNOWN
Last Update Posted:
2020-11-04
First Post:
2018-02-28
Brief Title:
Effects of Different Types of Physical Training in Patients With Pulmonary Arterial Hypertension
Sponsor:
University of Nove de Julho
Organization:
University of Nove de Julho
Study Overview
Official Title:
Effects of Combined Training Versus Aerobic Training Versus Respiratory Muscle Training in Patients With Pulmonary Hypertension A Randomized Controlled Clinical Trial
Status:
UNKNOWN
Status Verified Date:
2020-11
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PAH
Brief Summary:
Although there has been some progress in pharmacological management of PAH limited functional capacity and low survival still persist but there is evidence that exercise training can be accomplished without adverse effects or damage to cardiac function and pulmonary hemodynamics Specifically improvements in symptoms exercise capacity peripheral muscle function and quality of life Training programs need to be better studied and well defined and their physiological effects during physical training and functional capacity
The aim of this study is to compare the effects of different training exercises on physical performance indicators
The aim of this study is to compare the effects of different training exercises on physical performance indicators
Detailed Description:
Pulmonary arterial hypertension PAH is characterized by pathological changes in the pulmonary vasculature which cause an increase in pulmonary vascular resistance PVR restricting the flow of blood through the pulmonary circulation It is a serious illness progressive and usually fatal which causes significant functional limitation mainly due to dyspnea In order to maintain the flow of blood pulmonary artery pressure PAP increases and the disease progresses leading to right ventricular dysfunction and right heart failure
Regardless of the cause of PAH the pulmonary arteries and arterioles have reduced capacity and increases in cardiac output during exercise is limited As a result the delivery of oxygen to peripheral muscles is impaired contributing to the symptoms of fatigue and dyspnea While the limitation of the cardiac output to meet peripheral oxygen demand during exercise largely reduces exercise capacity musculoskeletal dysfunction may also be involved in the exercise limitation in patients with PAH Changes such as muscle atrophy decreased oxidative enzymes and a greater number of type II muscle fibers lead to an early lactic acidosis and decreased functional capacity A modest evidence exists that exercise training can be done without adverse effects or damage to cardiac and or pulmonary hemodynamics however the effectiveness PAH requires more research
Regardless of the cause of PAH the pulmonary arteries and arterioles have reduced capacity and increases in cardiac output during exercise is limited As a result the delivery of oxygen to peripheral muscles is impaired contributing to the symptoms of fatigue and dyspnea While the limitation of the cardiac output to meet peripheral oxygen demand during exercise largely reduces exercise capacity musculoskeletal dysfunction may also be involved in the exercise limitation in patients with PAH Changes such as muscle atrophy decreased oxidative enzymes and a greater number of type II muscle fibers lead to an early lactic acidosis and decreased functional capacity A modest evidence exists that exercise training can be done without adverse effects or damage to cardiac and or pulmonary hemodynamics however the effectiveness PAH requires more research
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None