Ignite Creation Date:
2024-05-05 @ 4:42 PM
Last Modification Date:
2024-10-26 @ 9:23 AM
Study NCT ID:
NCT00295555
Status:
COMPLETED
Last Update Posted:
2007-05-10
First Post:
2006-02-21
Brief Title:
Doxazosin Effects on ABPM in Hypertensive Patients With Diabetic Nephropathy
Sponsor:
Yokohama City University Medical Center
Organization:
Yokohama City University Medical Center
Study Overview
Official Title:
Effects of Doxazosin on Ambulatory Blood Pressure and Sympathetic Nervous Activity in Hypertensive Patients With Diabetic Nephropathy
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Few studies have reported the effect of alpha1-adrenergic antagonists on 24-h blood pressure and regulation of sympathetic nervous activity in hypertensive patients with diabetic nephropathy Using ambulatory blood pressure monitoring devices equipped with spectral analysis of heart rate variability we assess the effects of doxazosin on blood pressure in diabetic nephropathy patients and compare the results with those in patients with essential hypertension patients with diabetes mellitus and patients with chronic nephropathy
Detailed Description:
The study is an open-labeled parallel prospective trial comparing the effects of doxazosin 2-8 mgday on 24-h blood pressure and autonomic nervous activity Hypertensive patients with non-insulin-dependent diabetic nephropathy patients with essential hypertension patients with diabetes mellitus and patients with chronic nephropathy undergo ambulatory blood pressure monitoring before and after treatment with doxazosin Simultaneously spectral analysis is performed to calculate the high frequency components as a marker of parasympathetic nervous activity and the low frequency componentshigh frequency components ratios as an index of the sympathovagal balance
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None