Ignite Creation Date:
2024-05-06 @ 11:13 AM
Last Modification Date:
2024-10-26 @ 12:42 PM
Study NCT ID:
NCT03464084
Status:
COMPLETED
Last Update Posted:
2022-07-26
First Post:
2018-03-02
Brief Title:
Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2
Sponsor:
Brigham and Womens Hospital
Organization:
Brigham and Womens Hospital
Study Overview
Official Title:
Interaction of Melatonin and Light With MTNR1B Genotype on Glucose Control - Study 2
Status:
COMPLETED
Status Verified Date:
2022-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets
Detailed Description:
The investigators recent GWAS discovery of MTNR1B as a novel type 2 diabetes gene has sparked great interest into the role of melatonin in glycemic control for which the mechanism is largely unknown This research will determine the effect of melatonin and MTNR1B on glycemic control under highly-controlled in-laboratory protocols while manipulating circulating melatonin concentrations both up and down and assessing glycemic control by frequently-sampled intravenous glucose tolerance tests as well as in ex vivo human pancreatic islets This research will provide mechanistic insights into the metabolic effects of melatonin and the MTNR1B risk variant and may help in evidence-based approaches and personalized recommendations to improve glycemic control in night shift workers and late-night eaters
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DK102696 | NIH | None | httpsreporternihgovquickSearchR01DK102696 |